2. This figure shows a mutated allele that has a deletion between dashed lines. An individual is homozygous for this allele and has functional alleles for all other genes. Direction of transcription Chromosome 16 ZF chromosome 16 Ç a2 mRNA α1 mRNA α2 ZF deletion α2 α1 18 kb LUC7L normal transcription termination site LUC7L gene LUC7L mRNA LUC7L-02-globin fusion antisense RNA Elsevier. Nussbaum et al: Thompson and Thompson's Genetics in Medicine 7e - www.studentconsult.com

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Please help with this question. This is not a writing assignment like an expert kicked back to me. 

Part Three.
Suppose you are a lab technician who is responsible for diagnostic analysis of individual
hemoglobinopathy cases. You have identified the mutations in each individual as outlined in the list of
cases below. You will need to develop the appropriate techniques to identify these mutations in their
family members, predict how these mutations affect gene expression and confirm the prediction with
proper molecular techniques.
For each case, please decide which thalassemia the individual has and what level of gene expression
should be affected. Refer to the book when necessary.
Transcribed Image Text:Part Three. Suppose you are a lab technician who is responsible for diagnostic analysis of individual hemoglobinopathy cases. You have identified the mutations in each individual as outlined in the list of cases below. You will need to develop the appropriate techniques to identify these mutations in their family members, predict how these mutations affect gene expression and confirm the prediction with proper molecular techniques. For each case, please decide which thalassemia the individual has and what level of gene expression should be affected. Refer to the book when necessary.
2. This figure shows a mutated allele that has a deletion between dashed lines. An individual is
homozygous for this allele and has functional alleles for all other genes.
Direction of
transcription
Chromosome 16
ZF chromosome 16
Ç
α2 mRNA aα1 mRNA
ZF deletion
02
α1
18 kb
LUC7L normal transcription
termination site
LUC7L gene
LUC7L mRNA
LUC7L-02-globin fusion
antisense RNA
Ⓒ Elsevier. Nussbaum et al: Thompson and Thompson's Genetics in Medicine 7e - www.studentconsult.com
Transcribed Image Text:2. This figure shows a mutated allele that has a deletion between dashed lines. An individual is homozygous for this allele and has functional alleles for all other genes. Direction of transcription Chromosome 16 ZF chromosome 16 Ç α2 mRNA aα1 mRNA ZF deletion 02 α1 18 kb LUC7L normal transcription termination site LUC7L gene LUC7L mRNA LUC7L-02-globin fusion antisense RNA Ⓒ Elsevier. Nussbaum et al: Thompson and Thompson's Genetics in Medicine 7e - www.studentconsult.com
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