2. If a female with blood type AB mates with a male that has blood type B, what will be the phenotypes of their offspring. (in your answer please make sure to state the ratio of these phenotypes) 3. What A, B blood typing antigens and antibodies do each of the above parents have? |
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- III. LAB REPORT You inherited your blood type from your parents. Your blood type is based on antigens found on your red blood cells named A or B and antibodies found in your plasma called a or b. See Table 1 for the antigen-antibody make-up of different blood types. Table 1 Blood type Antigens Antibodies A A b B B a AB A and B neither a nor b O neither A nor B both a and b A. When would clumping (or agglutination occur? III. LAB REPORT You inherited your blood type from your parents. Your blood type is based on antigens found on your red blood cells named A or B and antibodies found in your plasma called a or b. See Table 1 for the antigen- antibody make-up of different blood types. Table 1 Blood type Antigens Antibodies A A B B a АВ A and B neither a nor b neither A nor B both a and b1. Suppose that the three samples are from two parents and their child. Which individuals are the parents? Which individual is the child? How do you know? Parent 1 = Parents 2 = Child = 2. What genotype must each individual have for this scenario to be possible? Parent 1 = Parent 2 = Child = please answer all of them now.
- 16. The Type A Transferase enzyme, attaches N-acetylgalactosamine (GalNAc) to H-antigen epitopes; the Type B Transferase enzyme instead transfers galactose (Gal) to the H-antigen. Individuals with Type A blood thus have at minimum one copy of the active Type A Transferase, those with Type B have at minimum one copy of the active Type B Transferase, those with Type AB have one active copy of each, those with Type O have neither. Imagine an AB individual who acquires a mutation in their Type B Transferase gene that allows it to be active with either Gal or GalNAc. Make sure to include a brief justification for your answer to each question below. a. What blood type antigens would this individual express? b. If this individual had a child with a normal O partner, what possible blood type antigens could the child express? c. If this individual had a child with a homozygous dominant B partner (BB), what possible blood type antigens could the child express?3-4. On the battlefield, a medic is treating a soldier who has lost a great deal of blood. They are out blood typing supplies so the medic, who is Type O negative, simply donates his own blood to the patien What is the possible explanation for this? a. A type O negative person has none of the proteins that can cause rejection in his blood, so his blood can be accepted by anyone. b. A type O do not have antibodies thus cannot make coagulation when mixed with any other blood types. c. It will not work since blood type O- have all the proteins on blood cells that serves as an antigen. d. There is no reference availabie that would support the action of the medic.2. The following is false about the junctional diversity of antibodies? A. insertion of none-coded nucleotides to the ends B. Insertion of pallindromic nucleotides to both ends C. TdT adds or remove nucleotides at the exposed ends of the V, D or J genes D. occurs exclusively in all lymphocytes including NK cells 3. The following is false about somatic hypermutation? A Are not transmitted to offspring B occurs in all T cells C occurs only within germinal centers D Activation-induced cytidine deaminase plays an important role E occurs in variable regions CDR hotspots of Ig genes H and L chains
- 2. please answer this6. QUESTION #6: In order to better understand the anatomical significance of blood type and the relationship between blood types, complete the below table: Table in which information regarding ABO blood type will be added for this assignment. To which blood From which blood types can an types can an Blood Type Antigen Present Antibody Produced individual with this individual with this blood type blood type receive donate? a donation? A ABFigure 42.16 The Rh antigen is found on Rh positive red blood cells. An Rh-negative female can usually carry an Rh-positive fetus to term without difficulty. However, if she has a second Rh-positive fetus, her body may launch an immune attack that causes hemolytic disease of the newborn. Why do you think hemolytic disease is only a problem during the second or subsequent pregnancies?
- You are solving for an unknown blood type. Drops of blood have been mixed with solutions containing the antibodies Anti- A, Anti-B and Anti-Rh. The test results are are pictured below. Using your knowledge of antibody- antigen interactions and the principle of agglutination, identify the blood type and answer the associated questions4. The function of allelic exclusion is? a. increase the magnitude of antibodies b. increase the affinity of antibodies c. increase the specificity of antibodies d. increase the diversity of antibodies e. increase sensitivity of antibodies1. A woman with type A+ blood can have a baby who's healthy with type B+ blood. Why wouldn't the baby have hemolytic transfusion reaction due to mom's anti-B?