Anatomy & Physiology
Anatomy & Physiology
1st Edition
ISBN: 9781938168130
Author: Kelly A. Young, James A. Wise, Peter DeSaix, Dean H. Kruse, Brandon Poe, Eddie Johnson, Jody E. Johnson, Oksana Korol, J. Gordon Betts, Mark Womble
Publisher: OpenStax College
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Chapter 18, Problem 7RQ

Which of the following plasma proteins is not produced by the liver?

  1. fibrinogen
  2. alpha globulin
  3. beta globulin
  4. immunoglobulin

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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine: (a) k, C0, V, and AUC* for the bolus iv data  (b) k, ka, B1, and AUC* for the po data  (c) k, ka, B1, and AUC* for the ip data  (d) relative bioavailability for po vs ip, Fpo/Fip  (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip    MAKE SURE ANSWERS HAVE UNITS if appropriate. SHOW ALL WORK, including equation used, variables used and each step to your solution.
2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0  Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present.  Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…
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Chapter 18 Solutions

Anatomy & Physiology

Ch. 18 - Which of the following statements about mature,...Ch. 18 - A molecule of hemoglobin ________. is shaped like...Ch. 18 - The production of healthy erythrocytes depends...Ch. 18 - Aging and damaged erythrocytes are removed from...Ch. 18 - A patient has been suffering for 2 months with a...Ch. 18 - The process by which leukocytes squeeze through...Ch. 18 - Which of the following describes a neutrophil?...Ch. 18 - T and B lymphocytes ________. are...Ch. 18 - A patient has been experiencing severe, persistent...Ch. 18 - Thrombocytes are more accurately called ________....Ch. 18 - The first step in hemostasis is ________. vascular...Ch. 18 - Prothrombin is converted to thrombin during the...Ch. 18 - Hemophilia is characterized by ________....Ch. 18 - The process in which antibodies attach to...Ch. 18 - People with ABO blood type O ________. have both...Ch. 18 - Hemolytic disease of the newborn is a risk during...Ch. 18 - A patients hematocrit is 42 percent. Approximately...Ch. 18 - Why would it be incorrect to refer to the formed...Ch. 18 - True or false: The buffy coat is the portion of a...Ch. 18 - Myelofibrosis is a disorder in which inflammation...Ch. 18 - Would you expect a patient with a form of cancer...Ch. 18 - A young woman has been experiencing unusually...Ch. 18 - A patient has thalassemia, a genetic disorder...Ch. 18 - One of the more common adverse effects of cancer...Ch. 18 - A patient was admitted to the burn unit the...Ch. 18 - A lab technician collects a blood sample in a...Ch. 18 - Explain why administration of a thrombolytic agent...Ch. 18 - Following a motor vehicle accident, a patient is...Ch. 18 - In preparation for a scheduled surgery, a patient...
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