Myasthenia gravis is a chronic autoimmune disorder in which antibodies attack components of the neuromuscular junction. Patients with this condition experience severe muscle weakness and dysfunction resulting in skeletal muscle fatigue, facial drooping, difficulty swallowing, double vision, unsteady walking, and a number of other symptoms. Approximately 90% of patients test positive for antibodies that are reactive to the acetylcholine receptor (AChR). Antibodies targeting the AChR effectively block this receptor, preventing its function. Under homeostatic conditions, explain the role of the AChR in skeletal muscle contraction.

Myasthenia gravis is a chronic autoimmune disorder in which antibodies attack components of the neuromuscular junction. Patients with this condition experience severe muscle weakness and dysfunction resulting in skeletal muscle fatigue, facial drooping, difficulty swallowing, double vision, unsteady walking, and a number of other symptoms. Approximately 90% of patients test positive for antibodies that are reactive to the acetylcholine receptor (AChR). Antibodies targeting the AChR effectively block this receptor, preventing its function. Under homeostatic conditions, explain the role of the AChR in skeletal muscle contraction.

Human Physiology: From Cells to Systems (MindTap Course List)

9th Edition

ISBN:9781285866932

Author:Lauralee Sherwood

Publisher:Lauralee Sherwood

Chapter12: Body Defenses

Section: Chapter Questions

Problem 14RE

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