19.43 Explain each statement. a. The pKa of p-nitrophenol is lower than the pKa of phenol (7.2 vs. 10). b. The pKa of p-nitrophenol is lower than the pKa of m-nitrophenol (7.2 vs. 8.3).
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- (17, 18, 5) Give the relative rates of reaction of the four carboxylic acid derivatives below with aqueous sodium hydroxide to give the sodium carboxylate salt.19.57 Because phenol (C6H5OH) is less acidic than a carboxylic acid, it can be deprotonated by NaOH but not by the weaker base NaHCO3. Using this information, write out an extraction sequence that can be used to separate C6H5OH, benzoic acid, and cyclohexanol. Show what compound is present in each layer at each stage of the process, and if it is present in its neutral or ionic form.16.41) Give on IUPAC or common home for each compound. 2 b. in O d. Hon de jha ok C. e- ion ganho-to- 0 y. ho Y 2-ethylbutonoyl chloride methyl benzoate N-ethyl-N-methylpropion amide ethyl formale benzoic propionic anhydride isopropyl 3-ethyl hexanoate
- 15.2 For each alcohol, give all combinations of Grignard reagent + carbonyl that will give the product. a. b. e. carbonyl carbonyl carbonyl Grignard Grignard Grignard H', quench H', quench H*, quench 400 OH + w OH OCH, Ph OHBoth pyridine and pyrrole are nitrogen-containing aromatic heterocyclic compounds (see below). When treated with HCI, pyridine forms a hydrochloride salt, whereas pyrrole is unreactive. Provide an explanation for this observed difference in reactivity. Pyridine (pK8.77) Pyrrole (pK, 17.8) Select one: O A. Protonation of pyrrole destroys a stable aromatic ring, while protonation of pyridine does not disrupt its aromaticity. OB. Reaction of pyrrole with HCI forms an unstable nitrogenous anion. OC. pyrdine is planar while pyrrole is not. OD. The pyrrole nitrogen is a strongly deactivating group. OE. Pyrrole has a large bond angle strain, preventing it from reacting. OF. Pyrrole is sterically hindered; pyridine is not.Compound H (C,H,O,) gives a precipitate when treated with hydroxylamine in aqueous ethanol and a silver mirror when treated with Tollens' solution. Following is its 'H-NMR spectrum. Deduce the structure of compound H. Compound H 2H IH IH IH 7 5 Chemical shift (8) 0 ppm 10 9. 8. 3. 2.
- Consider the para-substituted aromatic ketones, NO2C6H4COCH3 (p-nitroacetophenone) and CH3OC6H4COCH3 (p-methoxyacetophenone).a. Which carbonyl compound is more stable?b. Which compound forms the higher percentage of hydrate at equilibrium?c. Which compound exhibits a carbonyl absorption at higher wavenumber in its IR spectrum? Explain your reasoning ineach part.explain and show step by step how the product formed when phenyacetic acid is treated with reagents in letter L and K only. this is about carboxylic acid and its derivativesExplain step by step how did the compounds derived to their IUPAC name for letter b,f,h,k and l only.