1. Which of the following statements about the double negative (DN) population of developing thymocytes are true? a. All of these statements are true. b. Located in the cortex of the thymus. c. Subjected to beta selection as the first checkpoint in thymocyte maturation. d. Express the surrogate alpha chain (pTalpha) which pairs with a TCRbeta chain to form the preTCR. e. Turned on expression of RAG1/2 to form a rearranged TCRbeta chain via V/D/J recombination. 2. True or False: Cytotoxic CD8+ T cells can only kill one target cell once activated, since the release of cytotoxic molecules contained in their granules can also induce apoptosis in the T cell itself, as well as in surrounding healthy cells. a. True B. False 3. An important source of combinatorial diversity in lymphocyte antigen receptors is the splicing together of various V, D, and J gene segments. Which of these enzymes plays a key role in mediating combinatorial diversity during these rearrangements? Group of answer choices
Genetic Recombination
Recombination is crucial to this process because it allows genes to be reassorted into diverse combinations. Genetic recombination is the process of combining genetic components from two different origins into a single unit. In prokaryotes, genetic recombination takes place by the unilateral transfer of deoxyribonucleic acid. It includes transduction, transformation, and conjugation. The genetic exchange occurring between homologous deoxyribonucleic acid sequences (DNA) from two different sources is termed general recombination. For this to happen, an identical sequence of the two recombining molecules is required. The process of genetic exchange which occurs in eukaryotes during sexual reproduction such as meiosis is an example of this type of genetic recombination.
Microbial Genetics
Genes are the functional units of heredity. They transfer characteristic information from parents to the offspring.
1. Which of the following statements about the double negative (DN) population of developing thymocytes are true?
3. An important source of combinatorial diversity in lymphocyte antigen receptors is the splicing together of various V, D, and J gene segments. Which of these enzymes plays a key role in mediating combinatorial diversity during these rearrangements?
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