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1. The phosphorylation of glucose in the cell is coupled to the hydrolysis of ATP; that is, part of the free energy of ATP hydrolysis is used to phosphorylate glucose. The reactions involved are shown as follows: glucose + Pi ATP + H2O glucose 6-phosphate + H₂O ADP + Pi AGº' = 13.8 kJ/mol AG-30.5 kJ/mol Sum: glucose + ATP glucose 6-phosphate + ADP Calculate the Keq for the overall reaction of glucose phosphorylation. 2. Consider the oxidation of malate to oxaloacetate: malate + NAD+ - oxaloacetate + NADH + H+ Would you expect this reaction to proceed under standard condition and assuming that the appropriate enzyme is present? Support your answer with calculation. Hint: The following reactions are involved in this conversion: oxaloacetate + 2H + + 2e* NAD++ H+ + 2e malate E°' = -0.166 V NADH E°' = -0.320 V

1. The phosphorylation of glucose in the cell is coupled to the hydrolysis of ATP; that is, part of the free energy of ATP hydrolysis is used to phosphorylate glucose. The reactions involved are shown as follows: glucose + Pi ATP + H2O glucose 6-phosphate + H₂O ADP + Pi AGº' = 13.8 kJ/mol AG-30.5 kJ/mol Sum: glucose + ATP glucose 6-phosphate + ADP Calculate the Keq for the overall reaction of glucose phosphorylation. 2. Consider the oxidation of malate to oxaloacetate: malate + NAD+ - oxaloacetate + NADH + H+ Would you expect this reaction to proceed under standard condition and assuming that the appropriate enzyme is present? Support your answer with calculation. Hint: The following reactions are involved in this conversion: oxaloacetate + 2H + + 2e* NAD++ H+ + 2e malate E°' = -0.166 V NADH E°' = -0.320 V

Chemistry: The Molecular Science
Chemistry: The Molecular Science
5th Edition
ISBN:9781285199047
Author:John W. Moore, Conrad L. Stanitski
Publisher:John W. Moore, Conrad L. Stanitski
Chapter12: Chemical Equilibrium
Section: Chapter Questions
Problem 85QRT
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1. The phosphorylation of glucose in the cell is coupled to the hydrolysis of ATP; that is, part of the free energy of ATP hydrolysis is used to phosphorylate glucose. The reactions involved are shown as follows: glucose + Pi ATP + H2O glucose 6-phosphate + H₂O ADP + Pi AGº' = 13.8 kJ/mol AG-30.5 kJ/mol Sum: glucose + ATP glucose 6-phosphate + ADP Calculate the Keq for the overall reaction of glucose phosphorylation. 2. Consider the oxidation of malate to oxaloacetate: malate + NAD+ - oxaloacetate + NADH + H+ Would you expect this reaction to proceed under standard condition and assuming that the appropriate enzyme is present? Support your answer with calculation. Hint: The following reactions are involved in this conversion: oxaloacetate + 2H + + 2e* NAD++ H+ + 2e malate E°' = -0.166 V NADH E°' = -0.320 V
Transcribed Image Text:1. The phosphorylation of glucose in the cell is coupled to the hydrolysis of ATP; that is, part of the free energy of ATP hydrolysis is used to phosphorylate glucose. The reactions involved are shown as follows: glucose + Pi ATP + H2O glucose 6-phosphate + H₂O ADP + Pi AGº' = 13.8 kJ/mol AG-30.5 kJ/mol Sum: glucose + ATP glucose 6-phosphate + ADP Calculate the Keq for the overall reaction of glucose phosphorylation. 2. Consider the oxidation of malate to oxaloacetate: malate + NAD+ - oxaloacetate + NADH + H+ Would you expect this reaction to proceed under standard condition and assuming that the appropriate enzyme is present? Support your answer with calculation. Hint: The following reactions are involved in this conversion: oxaloacetate + 2H + + 2e* NAD++ H+ + 2e malate E°' = -0.166 V NADH E°' = -0.320 V
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