1. The image below shows the base cytosine and a methylated form of cytosine that occurs frequently in the human genome. Use your knowledge of DNA structure to answer these questions: a. Does methylation of cytosine affect its ability to base-pair with guanine? Explain. b. Could methylation of cytosine affect the binding of a protein that interacts with a C-G basepair in the major groove? Explain your answer.
1. The image below shows the base cytosine and a methylated form of cytosine that occurs frequently
in the human genome. Use your knowledge of DNA structure to answer these questions:
a. Does methylation of cytosine affect its ability to base-pair with guanine? Explain.
b. Could methylation of cytosine affect the binding of a protein that interacts with a C-G basepair in the major groove? Explain your answer.
Introduction
Methylation is a type of modification that occurs on DNA molecules, as well as on some RNA and protein molecules. It involves the addition of a methyl group (-CH3) to a specific site on the molecule. In the context of DNA, methylation usually refers to the addition of a methyl group to one of the four nitrogenous bases (cytosine, adenine, guanine, or thymine).
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