= 1. Oral dosing clinical tests are being planned for a new experimental antibiotic to assess urinary excretion parameters. Based on animal data scaled to humans, it is estimated that V = 0.8 L/kg, t1/2,elim 6.3 hr, F = 74%, fe,urine = 32%, and that the drug follows one- compartment pseudo-instantaneous oral absorption kinetics. Using these parameters, estimate the following for a 10 mg oral dose in a 70 kg subject: (a) How long urine must be collected to get 99% of the excreted drug (b) The total amount of unchanged drug excreted in urine (Ae,urine,∞) (c) The renal clearance, CLR
= 1. Oral dosing clinical tests are being planned for a new experimental antibiotic to assess urinary excretion parameters. Based on animal data scaled to humans, it is estimated that V = 0.8 L/kg, t1/2,elim 6.3 hr, F = 74%, fe,urine = 32%, and that the drug follows one- compartment pseudo-instantaneous oral absorption kinetics. Using these parameters, estimate the following for a 10 mg oral dose in a 70 kg subject: (a) How long urine must be collected to get 99% of the excreted drug (b) The total amount of unchanged drug excreted in urine (Ae,urine,∞) (c) The renal clearance, CLR
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Answer parts a, b and c for question 1
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1. Oral dosing clinical tests are being planned for a new experimental antibiotic to assess
urinary excretion parameters. Based on animal data scaled to humans, it is estimated that V
= 0.8 L/kg, t1/2,elim 6.3 hr, F = 74%, fe,urine = 32%, and that the drug follows one-
compartment pseudo-instantaneous oral absorption kinetics. Using these parameters,
estimate the following for a 10 mg oral dose in a 70 kg subject:
(a) How long urine must be collected to get 99% of the excreted drug
(b) The total amount of unchanged drug excreted in urine (Ae,urine,∞)
(c) The renal clearance, CLR
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