1. Define the following terms in the context of Drug Discovery and Development. (2 pts each)(a) Target(b) Hit(c) Lead(d) Lead Optimization(e) Investigational New Drug (IND)(f) New Drug Application (NDA)(g) Pharmacodynamics(h) Pharmacokinetics(i) Absorption(j) Distribution(k) Metabolism(I) Excretion(m) Toxicity(n) Phenotype-based drug discovery(o) Target-based drug discovery

A Detailed Explanation with References:(a) TargetDefinition: In drug discovery, a target is a…

Answered: 1. Define the following terms in the…

Chemistry: The Molecular Science

5th Edition

ISBN:9781285199047

Author:John W. Moore, Conrad L. Stanitski

Publisher:John W. Moore, Conrad L. Stanitski

Chapter13: The Chemistry Of Solutes And Solutions

Section: Chapter Questions

Problem 57QRT

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The avg. toxicity of animal-based foods is about 0.4pg (picogram) of TCDD equivalent per 1g of food, and the LD50for 2,3,7,8 - TCDD is about 0.001 mg per kg of body weight. What mass, in kg, of animal-based food would you have to consume to ingest a fatal dose of it? (Assume your body mass is 60 kg.)
I Part 3 Discussion questions: Please answer in less than 2 paragraphs (20 points) 1. The FDA scientists have published 2 papers on the subject of sunscreen dermal absorption. What is different between the publications? The editorial page in the journal JAMA (Journal of American Medication Association) might help you answer this question.
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a) Lysine is an essential amino acid. It is taken by some people as a nutritional supplement in the form of a hydrated crystalline solid with the formula C6H₁4N2O2.XH₂O . To control the dose of lysine, it is essential to know the complete formula of the hydrate, which means determining the value of x. To determine the value of x in lysine hydrate, a pharmacist used a direct titration method. She dissolved 6.258g of the compound in approximately 100mL of distilled water and then made this up to 250mL in a volumetric flask. She then titrated 25mL aliquots of this solution with a standardized NaOH solution of concentration 0.1050 mol dm-³, obtaining a mean titre of 36.30 mL. In titrations, lysine behaves as a monoprotic acid. Use these data to determine the value of x in lysine hydrate. b) In a second experiment to verify the value of x, the pharmacist heated a 3.752g sample of the lysine hydrate to drive off all the water. When she reweighed the sample, the mass was 3.278 g. Use this…
Tom, an analytical chemist, bought a bag of decaffeinated coffee from a grocery store. However,Tom suspected that he might have received regular coffee and therefore decided to analyze hiscoffee for caffeine. In the lab, he took 0.5 mL of the brewed coffee and diluted it in water tomake a 100.0 mL solution. He performed four analyses and found the concentrations to be 4.69,3.99, 4.12, and 4.50 mg/L, respectively. (Assume the density of all solutions is 1.000 g/mL,1oz= 28.35 mL).(a) Report the concentration (in mg/L) of caffeine in the brewed coffee using the format asaverage ± standard deviation. (Note this is not the concentration in the diluted solution.)(b) Look up the caffeine content of regular vs. decaffeinated coffee. Do you think that Tom wasgiven the wrong type of coffee?(c) Caffeine intake of 300 mg per day reportedly has no adverse effects in the vast majority ofthe adult population. If Tom drinks 3 cups (8 oz/cup) of this coffee daily, is his intake withinthis known safe…
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2. What quantity should be dispensed when 50 mg of amitryptyline has been prescribed two times per day for 2 weeks, if the medication shown below is all that is available? Amitriptyline HCI Tablets, USP 25 mg 1000 TABLETS R only 0781-1487-10 6 Each tablet contains: Amitriptyline HCI, USP Usual Dosage: See package insert. Store at controlled room temperature 150-30°C (59⁰. 86°F). Dispense in a tight, light-resistant container. KEEP THIS AND ALL DRUGS OUT OF THE REACH OF CHILDREN. Rev. 09-2001M Manufactured By Geneva Pharmaceuticals, Inc. Broomfield, CO 80020 25 mg Geneva SPECIMEN PHARMACEUTICALS
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Study guide 29 Option A.)[Option 1] “Shift A” Option B.) [Option 2] “Shift B”
What would be an appropriate shelf-life, t90, for this drug (in days) in this solution?
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