1. Define the following terms in the context of Drug Discovery and Development. (2 pts each)(a) Target(b) Hit(c) Lead(d) Lead Optimization(e) Investigational New Drug (IND)(f) New Drug Application (NDA)(g) Pharmacodynamics(h) Pharmacokinetics(i) Absorption(j) Distribution(k) Metabolism(I) Excretion(m) Toxicity(n) Phenotype-based drug discovery(o) Target-based drug discovery

A Detailed Explanation with References:(a) TargetDefinition: In drug discovery, a target is a…

Answered: 1. Define the following terms in the…

Chemistry: The Molecular Science

5th Edition

ISBN:9781285199047

Author:John W. Moore, Conrad L. Stanitski

Publisher:John W. Moore, Conrad L. Stanitski

Chapter13: The Chemistry Of Solutes And Solutions

Section: Chapter Questions

Problem 57QRT

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1. Match the terms given in Column I with the compounds given in Column II. Column I (i) Acid rain(ii) Photochemical smog(iii) Combination with haemoglobin(iv) Depletion of ozone layer Column II (a) CHCl2 – CHF2(b) CO(c) CO2(d) SO2(e) Unsaturated hydrocarbons
I Part 3 Discussion questions: Please answer in less than 2 paragraphs (20 points) 1. The FDA scientists have published 2 papers on the subject of sunscreen dermal absorption. What is different between the publications? The editorial page in the journal JAMA (Journal of American Medication Association) might help you answer this question.
6
A direct enzyme-linked immunosorbent assay (ELISA) test on a patient's sample is shown below. Development of a strong (dark) color reaction would indicate: 1 Antibody is adsorbed to well. 2 Patient sample is added; complementary antigen binds to antibody. 3 Enzyme-linked antibody specific 4 Enzyme's substrate () is added, for test antigen is added and binds and reaction produces a product that causes a visible color change (O). to antigen, forming sandwich. A low concentration of a specific antigen in the patient's sample O A high concentration of a specific enzyme in the patient's sample The patient's antibody is specific for the enzyme's substrate O A high concentration of a specific antigen in the patient's sample A high concentration of a specific antibody (against the test antigen) in the patient's sample
2. What quantity should be dispensed when 50 mg of amitryptyline has been prescribed two times per day for 2 weeks, if the medication shown below is all that is available? Amitriptyline HCI Tablets, USP 25 mg 1000 TABLETS R only 0781-1487-10 6 Each tablet contains: Amitriptyline HCI, USP Usual Dosage: See package insert. Store at controlled room temperature 150-30°C (59⁰. 86°F). Dispense in a tight, light-resistant container. KEEP THIS AND ALL DRUGS OUT OF THE REACH OF CHILDREN. Rev. 09-2001M Manufactured By Geneva Pharmaceuticals, Inc. Broomfield, CO 80020 25 mg Geneva SPECIMEN PHARMACEUTICALS
Study guide 29 Option A.)[Option 1] “Shift A” Option B.) [Option 2] “Shift B”
What would be an appropriate shelf-life, t90, for this drug (in days) in this solution?
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d) (2 pts) BHCI CH3 + H₂C 1. Mix 2. NaOH, H₂O₂ D
1. Which is a false statement regarding solid-phase synthesis? (a) It simplifies removal of solvents (b) It simplifies automation of reactions (c) It simplifies monitoring of reactions (d) It simplifies reproducibility of reactions (e) It simplifies removal of soluble reagents 2. Which is a main advantage of solid-phase synthesis? (a) It simplifies purification of products (b) It can be performed on a large scale (c) It simplifies monitoring of reactions (d) It requires less amount of reagents (e) It simplifies characterisation of intermediates

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