1. Amino acid side chains act as nucleophiles and proton donor/acceptors in various enzymatic reactions. We will use them frequently in reactions during 40B and therefore the purpose of this exercise is to review the properties of amino acid side chains you have learned in 40A. Ozempic is a medication used for the treatment of type 2 diabetes and an anti-obesity treatment. Ozempic is a modified peptide that mimics the structure of the natural hormone GLP-1. H-His-Gu-Gy- The Phe-The-Ser Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gin-Ala-Ala-qu Ph H₂C CH₂ a. Glu Phe-lle Ala-Trp Leu-Val-Arg-Gly Arg-Gly-OH Add above the tree-letter code of each amino acid the relevant functional group on its side chain OH I For example: -Ser- will be represented by Ser OH C. b. The protonation state of each functional group depends on the pH of the solution. Assume that Ozempic is in a solution at pH=7. Draw the functional groups at their correct protonation form. Gu-Gay-Thr Phe-Thr-Ser Asp-Val-Ser-Ser-Tyr-Leu-Gu-Gly-Gin-Ala-Ala-Gu Phe-fie- Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly-OH H₂C CH₂ What will be the protonation state of the long non-peptide side chain at pH=7?
1. Amino acid side chains act as nucleophiles and proton donor/acceptors in various enzymatic reactions. We will use them frequently in reactions during 40B and therefore the purpose of this exercise is to review the properties of amino acid side chains you have learned in 40A. Ozempic is a medication used for the treatment of type 2 diabetes and an anti-obesity treatment. Ozempic is a modified peptide that mimics the structure of the natural hormone GLP-1. H-His-Gu-Gy- The Phe-The-Ser Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gin-Ala-Ala-qu Ph H₂C CH₂ a. Glu Phe-lle Ala-Trp Leu-Val-Arg-Gly Arg-Gly-OH Add above the tree-letter code of each amino acid the relevant functional group on its side chain OH I For example: -Ser- will be represented by Ser OH C. b. The protonation state of each functional group depends on the pH of the solution. Assume that Ozempic is in a solution at pH=7. Draw the functional groups at their correct protonation form. Gu-Gay-Thr Phe-Thr-Ser Asp-Val-Ser-Ser-Tyr-Leu-Gu-Gly-Gin-Ala-Ala-Gu Phe-fie- Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly-OH H₂C CH₂ What will be the protonation state of the long non-peptide side chain at pH=7?
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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