(1) Part of the biosynthesis of the polyketide lovastatin is shown below. (a)Using a reaction mechanism, explain the conversion of A into B using the co-factor SAM. SEnz SEnz B (b) Then explain the conversion of C into D with two separate inputs of malonyl-CoA. Include in your answer mechanisms for the transformations, additional co-factors involved and briefly describe the transformations occurring. SEnz SEnz COSENZ D エ山

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(1) Part of the biosynthesis of the polyketide lovastatin is shown below.
(a)Using a reaction mechanism, explain the conversion of A into B using the co-factor SAM.
SEnz
SEnz
A
(b) Then explain the conversion of C into D with two separate inputs of malonyl-CoA. Include in your answer
mechanisms for the transformations, additional co-factors involved and briefly describe the transformations
occurring.
SEnz
COSENZ
D
エ山
Transcribed Image Text:(1) Part of the biosynthesis of the polyketide lovastatin is shown below. (a)Using a reaction mechanism, explain the conversion of A into B using the co-factor SAM. SEnz SEnz A (b) Then explain the conversion of C into D with two separate inputs of malonyl-CoA. Include in your answer mechanisms for the transformations, additional co-factors involved and briefly describe the transformations occurring. SEnz COSENZ D エ山
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