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Question 3. AMDH enzyme SH B: (base) In one step of tryptophane catabolism, the enzyme aminomuconate- semialdehyde dehydrogenase (AMDH) catalyzes the oxidation of 2-amino muconate semialdehyde to 2-amino muconate according the the overal scheme below. The reaction proceeds through a 2-amino muconate thioester intermediate (not shown) produced through the action of a cofactor NADP+. H NH3* 2-amino muconate CO₂ semialdehyde Structure of NADP+: NH3 AMDH enzyme a) Draw the structure of NADP+ (you can abbreviate ADP as R). CO₂ NADP+ - NADPH NH3+ CO₂ 2-amino muconate b) Provide a detailed arrow-pushing mechanism for the formation of 2-amino muconate from 2-amino muconate semialdehyde. NH3 CO₂

Question 3. AMDH enzyme SH B: (base) In one step of tryptophane catabolism, the enzyme aminomuconate- semialdehyde dehydrogenase (AMDH) catalyzes the oxidation of 2-amino muconate semialdehyde to 2-amino muconate according the the overal scheme below. The reaction proceeds through a 2-amino muconate thioester intermediate (not shown) produced through the action of a cofactor NADP+. H NH3* 2-amino muconate CO₂ semialdehyde Structure of NADP+: NH3 AMDH enzyme a) Draw the structure of NADP+ (you can abbreviate ADP as R). CO₂ NADP+ - NADPH NH3+ CO₂ 2-amino muconate b) Provide a detailed arrow-pushing mechanism for the formation of 2-amino muconate from 2-amino muconate semialdehyde. NH3 CO₂

Chemistry
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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Question 3. AMDH enzyme SH B: (base) In one step of tryptophane catabolism, the enzyme aminomuconate- semialdehyde dehydrogenase (AMDH) catalyzes the oxidation of 2-amino muconate semialdehyde to 2-amino muconate according the the overal scheme below. The reaction proceeds through a 2-amino muconate thioester intermediate (not shown) produced through the action of a cofactor NADP+. H NH3* 2-amino muconate CO₂ semialdehyde Structure of NADP+: NH3 AMDH enzyme a) Draw the structure of NADP+ (you can abbreviate ADP as R). CO₂ NADP+ - NADPH NH3+ CO₂ 2-amino muconate b) Provide a detailed arrow-pushing mechanism for the formation of 2-amino muconate from 2-amino muconate semialdehyde. NH3 CO₂
Transcribed Image Text:Question 3. AMDH enzyme SH B: (base) In one step of tryptophane catabolism, the enzyme aminomuconate- semialdehyde dehydrogenase (AMDH) catalyzes the oxidation of 2-amino muconate semialdehyde to 2-amino muconate according the the overal scheme below. The reaction proceeds through a 2-amino muconate thioester intermediate (not shown) produced through the action of a cofactor NADP+. H NH3* 2-amino muconate CO₂ semialdehyde Structure of NADP+: NH3 AMDH enzyme a) Draw the structure of NADP+ (you can abbreviate ADP as R). CO₂ NADP+ - NADPH NH3+ CO₂ 2-amino muconate b) Provide a detailed arrow-pushing mechanism for the formation of 2-amino muconate from 2-amino muconate semialdehyde. NH3 CO₂
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