(b) The sequence below depicts part of a total synthesis of 5-epi-prelactone B.Me3SiO4HO1 coHCO₂MeMe3SICINEt3Me SiOMe Sio23HCO₂MeDraw a curved arrow mechanism for the conversion of aldehyde 1 to silyl ether 2.Suggest reagents and conditions for the conversion of silyl ether 2 to alkene 3, provide acurved arrow mechanism for this transformation and explain briefly comment on anyissues of selectivity that arise.Suggest reagents and conditions for the conversion of alkene 3 to cyclopropane 4.

The objective of this question is to show the organic synthesis or conversion by using different…

) The sequence below depicts part of a total synthesis of 5-epi-prelactone B. Me3SiQ HO 1 H CO₂Me Me3SICI NEt3 Me SiQ Me3SiO 2 3 H CO₂Me Draw a curved arrow mechanism for the conversion of aldehyde 1 to sily

) The sequence below depicts part of a total synthesis of 5-epi-prelactone B. Me3SiQ HO 1 H CO₂Me Me3SICI NEt3 Me SiQ Me3SiO 2 3 H CO₂Me Draw a curved arrow mechanism for the conversion of aldehyde 1 to sily

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

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(b) The sequence below depicts part of a total synthesis of 5-epi-prelactone B.
Me3SiO
4
HO
1 co
H
CO₂Me
Me3SICI
NEt3
Me SiO
Me Sio
2
3
H
CO₂Me
Draw a curved arrow mechanism for the conversion of aldehyde 1 to silyl ether 2.
Suggest reagents and conditions for the conversion of silyl ether 2 to alkene 3, provide a
curved arrow mechanism for this transformation and explain briefly comment on any
issues of selectivity that arise.
Suggest reagents and conditions for the conversion of alkene 3 to cyclopropane 4.

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Step 2: Reaction involved

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Step 3: Mechanism of action

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Step 4: Conversion of Silyl Ether 2 to Alkene 3:

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Step 5: Conversion of Alkene 3 to Cyclopropane 4:

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