4. Compound Y below is a glucocorticoid that can be acted on by special monooxygenase enzymes in the body to form Compound Z. Certain gut microbes, however, possess TPP-dependent enzymes that catalyze the same transformation. Using the structural abbreviation provided below, provide a complete curved-arrow mechanism for this transformation, and draw the structure of the co-product in the box at right. ОН Мe Me HO HO Ме H TPP Me H H Compound Y Compound Z Co-product

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4. Compound Y below is a glucocorticoid that can be acted on by special monooxygenase enzymes in the body to
form Compound Z. Certain gut microbes, however, possess TPP-dependent enzymes that catalyze the same
transformation. Using the structural abbreviation provided below, provide a complete curved-arrow mechanism for
this transformation, and draw the structure of the co-product in the box at right.
ОН
Ме
Ме
HO,
HO
HO"
Ме
H
TPP
Me
H
H
Compound Y
Compound Z
Co-product
ОН
Me
HO"
Structural abbreviation
for Compound Y
Transcribed Image Text:4. Compound Y below is a glucocorticoid that can be acted on by special monooxygenase enzymes in the body to form Compound Z. Certain gut microbes, however, possess TPP-dependent enzymes that catalyze the same transformation. Using the structural abbreviation provided below, provide a complete curved-arrow mechanism for this transformation, and draw the structure of the co-product in the box at right. ОН Ме Ме HO, HO HO" Ме H TPP Me H H Compound Y Compound Z Co-product ОН Me HO" Structural abbreviation for Compound Y
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