1. The total synthesis of Pironetin was accomplished using several steps we have learned this semester. Some steps are shown below. For each step of the synthesis, identify the functional group transformation that occurs, and provide reagents that will accomplish this transformation. Functional Group Transformation TBS он OR O OPМВ TBS OTs OR O OPMB (a) 1° Alcohol to Tosylate TBS TBS OTs OR O OPMB OR O OPMB (b) ÇH3 TBS TBS OR O OPMB OR ОРМB CH3 CH, TBS OR O OR (d) TBS OR O OR CH3 TBS OR O OH CH3 TBS OR TBS = CH3 ОMe ОН О PMB Pironetin OMe

1. The total synthesis of Pironetin was accomplished using several steps we have learned this semester. Some steps are shown below. For each step of the synthesis, identify the functional group transformation that occurs, and provide reagents that will accomplish this transformation. Functional Group Transformation TBS он OR O OPМВ TBS OTs OR O OPMB (a) 1° Alcohol to Tosylate TBS TBS OTs OR O OPMB OR O OPMB (b) ÇH3 TBS TBS OR O OPMB OR ОРМB CH3 CH, TBS OR O OR (d) TBS OR O OR CH3 TBS OR O OH CH3 TBS OR TBS = CH3 ОMe ОН О PMB Pironetin OMe

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

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