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1. The total synthesis of Pironetin was accomplished using several steps we have learned this semester. Some steps are shown below. For each step of the synthesis, identify the functional group transformation that occurs, and provide reagents that will accomplish this transformation. Functional Group Transformation TBS он OR O OPМВ TBS OTs OR O OPMB (a) 1° Alcohol to Tosylate TBS TBS OTs OR O OPMB OR O OPMB (b) ÇH3 TBS TBS OR O OPMB OR ОРМB CH3 CH, TBS OR O OR (d) TBS OR O OR CH3 TBS OR O OH CH3 TBS OR TBS = CH3 ОMe ОН О PMB Pironetin OMe

1. The total synthesis of Pironetin was accomplished using several steps we have learned this semester. Some steps are shown below. For each step of the synthesis, identify the functional group transformation that occurs, and provide reagents that will accomplish this transformation. Functional Group Transformation TBS он OR O OPМВ TBS OTs OR O OPMB (a) 1° Alcohol to Tosylate TBS TBS OTs OR O OPMB OR O OPMB (b) ÇH3 TBS TBS OR O OPMB OR ОРМB CH3 CH, TBS OR O OR (d) TBS OR O OR CH3 TBS OR O OH CH3 TBS OR TBS = CH3 ОMe ОН О PMB Pironetin OMe

Chemistry
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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1. The total synthesis of Pironetin was accomplished using several steps we have learned this semester. Some steps are shown below. For each step of the synthesis, identify the functional group transformation that occurs, and provide reagents that will accomplish this transformation. Functional Group Transformation TBS он OR O ОРМВ TBS OTs OR O ОРМB (a) 1° Alcohol to Tosylate TBS TBS OR O OPMB OTs OR O ОРМВ (b) H TBS TBS (c) OR O ОРМB OR O OPMB CH3 CH3 (d) TBS TBS OR O OR OR O OR' CH3 TBS CH3 (e) OR O TBS OR O OH TBS= CH3 ОMe Oн О PMB OMe Pironetin
Transcribed Image Text:1. The total synthesis of Pironetin was accomplished using several steps we have learned this semester. Some steps are shown below. For each step of the synthesis, identify the functional group transformation that occurs, and provide reagents that will accomplish this transformation. Functional Group Transformation TBS он OR O ОРМВ TBS OTs OR O ОРМB (a) 1° Alcohol to Tosylate TBS TBS OR O OPMB OTs OR O ОРМВ (b) H TBS TBS (c) OR O ОРМB OR O OPMB CH3 CH3 (d) TBS TBS OR O OR OR O OR' CH3 TBS CH3 (e) OR O TBS OR O OH TBS= CH3 ОMe Oн О PMB OMe Pironetin
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