1. Polyketide synthesis (PKS) is a process by which many natural products such as macrolide antibiotics (e.g., erythromycin) are made. An important part of this process is the reduction of formed ketones to alcohols using a domain known as a keto-reductase. Keto-reductase catalyzes the delivery of hydride from NAD(P)H to the ketone. Provide a logical reaction mechanism using the arrow formalism. Enz Enz : нн .R Keto Reductase R HO N. HO- HO- NH2 CH3 0oC. ÑH ОН ОН

1. Polyketide synthesis (PKS) is a process by which many natural products such as macrolide antibiotics (e.g., erythromycin) are made. An important part of this process is the reduction of formed ketones to alcohols using a domain known as a keto-reductase. Keto-reductase catalyzes the delivery of hydride from NAD(P)H to the ketone. Provide a logical reaction mechanism using the arrow formalism. Enz Enz : нн .R Keto Reductase R HO N. HO- HO- NH2 CH3 0oC. ÑH ОН ОН

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

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