. Mutations in an autosomal gene in humans cause aform of hemophilia called von Willebrand disease(vWD). This gene specifies a blood plasma proteincleverly called von Willebrand factor (vWF). vWFstabilizes factor VIII, a blood plasma protein specified by the wild-type hemophilia A gene. Factor VIIIis needed to form blood clots. Thus, factor VIII is rapidly destroyed in the absence of vWF.Which of the following might successfully be employed in the treatment of bleeding episodes in hemophiliac patients? Would the treatments workimmediately or only after some delay needed forprotein synthesis? Would the treatments have only ashort-term or a prolonged effect? Assume that allmutations are null (that is, the mutations result in thecomplete absence of the protein encoded by the gene)and that the plasma is cell-free.a. transfusion of plasma from normal blood into avWD patientb. transfusion of plasma from a vWD patient into adifferent vWD patientc. transfusion of plasma from a hemophilia A patientinto a vWD patientd. transfusion of plasma from normal blood into a hemophilia A patiente. transfusion of plasma from a vWD patient into ahemophilia A patient
. Mutations in an autosomal gene in humans cause a
form of hemophilia called von Willebrand disease
(vWD). This gene specifies a blood plasma protein
cleverly called von Willebrand factor (vWF). vWF
stabilizes factor VIII, a blood plasma protein specified by the wild-type hemophilia A gene. Factor VIII
is needed to form blood clots. Thus, factor VIII is rapidly destroyed in the absence of vWF.
Which of the following might successfully be employed in the treatment of bleeding episodes in hemophiliac patients? Would the treatments work
immediately or only after some delay needed for
protein synthesis? Would the treatments have only a
short-term or a prolonged effect? Assume that all
mutations are null (that is, the mutations result in the
complete absence of the protein encoded by the gene)
and that the plasma is cell-free.
a. transfusion of plasma from normal blood into a
vWD patient
b. transfusion of plasma from a vWD patient into a
different vWD patient
c. transfusion of plasma from a hemophilia A patient
into a vWD patient
d. transfusion of plasma from normal blood into a hemophilia A patient
e. transfusion of plasma from a vWD patient into a
hemophilia A patient
Trending now
This is a popular solution!
Step by step
Solved in 2 steps
