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4102

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Health Science

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Oct 30, 2023

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©Dr. Ron Saulnier HSS 4102 A Fall 2023 Developmental Origins of Health and Disease HSS 4102 A

©Dr. Ron Saulnier HSS 4102 A Fall 2023 DOHaD https://www.dohad2022.com/ “The Developmental Origin of Health and Disease (DOHaD) theory is based on the concept that the origins of lifestyle-related disease is formed at the time of fertilization, embryonic, fetal, and neonatal stages by the interrelation between genes and the environments (nutrition, stress, or environmental chemicals).” https://www.cambridge.org/core/journals/journal-of- developmental-origins-of-health-and-disease

©Dr. Ron Saulnier HSS 4102 A Fall 2023 DOHaD Poston, Lucilla, editor.; Godfrey, Keith (Keith M.), editor.; Gluckman, Peter D., editor.; Hanson, Mark A., editor. 2023 Access via Uottawa library

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©Dr. Ron Saulnier HSS 4102 A Fall 2023 A few points to keep in mind • DOHaD will open new doors in the prevention and management of chronic illness but may also raise concerns in the general population that do not understand. • Many factors contribute to long-term health, not just those early in life that we see in this course. • Try to understand the course material more than memorize it and find links between the different topics. • Convince yourself that you want to learn the material, not that you have to learn the material. • Try to use a cascade approach to learning instead of the shotgun approach to learning.

©Dr. Ron Saulnier HSS 4102 A Fall 2023 HSS 4102 A Part 1: Course Information Title: Developmental Origins of Health and Disease Prefix/Section: HSS 4102 A Credits: 3 Begins/Ends: Sept 6 th 2023 to Dec 6 th 2023 Meeting Day/Time: Mondays 5:30-6:50 pm and Wednesdays 5:30-6:50 pm (The course will be composed of synchronous In class lectures) Last Day to Withdraw: Check University calendar Delivery Type: Classroom Lectures, readings and video Class Location: Online- Brightspace along with other platforms Course Website: Virtual campus- Brightspace

©Dr. Ron Saulnier HSS 4102 A Fall 2023 Instructor Information Professor names: Dr. Ron Saulnier Office Location: Thompson 119 or Zoom Office Hours: Dr. Saulnier: Tuesday 5:00 – 6:00. Other times can be available if necessary. On line office hours Wednesday 12-1 pm (links on Brightspace) E-mail: rsaulnie@uottawa.ca ,

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©Dr. Ron Saulnier HSS 4102 A Fall 2023 Course Description& Prerequisite Course Description Developmental perspectives on health, behaviours, disease and disability. Study of developmental plasticity, related mechanisms and potential role in the etiology of health problems. Course Attendance Requirements: The professor will not provide recordings for an in-person course unless weather conditions pose a risk to students coming to class. Attendance is strongly recommended so that students hear any announcements or discussions given in class and to hear the class material explained. Prerequisite: Prerequisites: 81 university units and HSS 3305. Required Text No formal textbook is assigned to the course. Several PDF papers will be provided on Brightspace, along with course notes, which will serve as the course material.

©Dr. Ron Saulnier HSS 4102 A Fall 2023 Course Structure  A Powerpoint copy and PDF of the course notes (no audio) will be available on Brightspace for the duration of the term. No recordings are provided unless there are extenuating circumstances such as a snowstorm or the professor is ill.  A written scenario assignment with questions for the student to research will be assigned to motivate the student to stay up-to-date with the course material. It can be done individually or in pairs and submitted on Brightspace by the due date.  A term infographic assignment is also assigned for students to complete either individually or in pairs and submitted on Brightspace by the due date.  The course will contain an in class written midterm and final exam.  Students will also be evaluated with an in-class midterm and final exam composed on multiple choice questions and short answer questions.

©Dr. Ron Saulnier HSS 4102 A Fall 2023 Sessional dates and deferrals Sessional Dates Classes Begin: Sept 6 th 2023 Thanksgiving: Oct 9 th , 2023 Study Break: Oct 22 nd to 28 th , 2023 Course Evaluations: Nov 22 nd to Dec 1 st , 2023 Classes End: Dec 6 th, 2023 Exam Period:Dec 8 th to Dec 21 st , 2023 Deferred midterm and exam dates: Fall Session : Midterm deferral dates Nov 13 th – 16 th 2023 or Jan 4 th & 5 th , 2024 Final Exam Deferral dates Jan 4 th & 5 th , 2024

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©Dr. Ron Saulnier HSS 4102 A Fall 2023 Learning Objectives 1. Mechanisms by which predisposing factors (e.g. psychosocial, stressors, environmental factors etc.) modulate development (“developmental plasticity”) and influence health, disease and disability MIDTERM, FINAL 2. Protective factors during fetal, neonatal development and early childhood which contribute to the development of longevity MIDTERM, FINAL 3. Basic concepts and notions of the development of living organisms (ontogenesis) including periods of plasticity beyond the neonatal-pediatric stages. MIDTERM, FINAL 4. The main theories of the developmental origins of health problems. MIDTERM, FINAL 5. Strategies for minimizing or preventing developmental risks to optimize long- term health outcomes MIDTERM, FINAL, ASSIGNMENTS Specific Learning Outcomes By the end of this course, students can be expected to 1. Understand the concepts and theories related to the development of organisms-“ontogenesis” MIDTERM, FINAL 2. Identify periods of developmental plasticity throughout the lifespan MIDTERM, FINAL 3. Describe mechanisms that underlie developmental plasticity MIDTERM, FINAL 4. Apply the theoretical principles of the Developmental Origins of Health and Disease (DOHaD) hypothesis to understanding the etiology of health problems and development of longevity MIDTERM, FINAL, ASSIGNMENT 5. Propose effective methods of prevention to minimize developmental risks to later onset of health problems. MIDTERM, FINAL, ASSIGNMENT

©Dr. Ron Saulnier HSS 4102 A Fall 2023 Lecture outline Course Syllabus WEEK 1 (Sept 6 th ) - Introductory lecture – (RS) Module 1 Conceptual framworks of DoHAD (Sept 11-20)  Lecture 1 – Intro to DOHaD Frameworks (RS)  Lecture 2 – Overview of DOHaD Mechanisms (RS)  Lecture 3 – Epigenetics and disease (RS) Module 2 Prenatal window of plasticity and the placenta (Sept 25-Oct 2)  Lecture 1 – The Prenatal period and pregnancy ( RS )  Lecture 2 – Placenta part 1 ( RS )  Lecture 3 – placenta part 2 ( RS )

©Dr. Ron Saulnier HSS 4102 A Fall 2023 Lecture outline Module 3 The fetal brain and HPA axis (Oct 54 - 11)  Lecture 1 – Fetal Brain development (RS)  Lecture 2 – HPA Axis part (RS) Module 4 Gut development, the microbiome (Oct 16-30) -  Lecture 1 – Gut development and Microbiome part 1 (RS)  Lecture 2 – Microbiome part 2 (RS) (Oct 23-27) – READING WEEK

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©Dr. Ron Saulnier HSS 4102 A Fall 2023 Lecture outline MIDTERM Nov 1 st , 2022 Module 5 ( Early windows of plasticity and role of micronutrients) WEEK 10 and 11 (Nov 6– 15)  Lecture 1 – Gametogenesis and fertilization ( RS )  Lecture 2 – Fertility and ARTs ( RS )  Lecture 3 – Diet and micronutrient deficiency ( RS )  Lecture 4 – Dietary components during pregnancy (RS) Module 6 Endocrine disruption and teratogenesis (Nov 20 – Dec 6)  Lecture 1 – Genetic damage and transmission (RS)  Lecture 2 – Endocrine disruption part 1 ( RS )  Lecture 3 – Endocrine disruption part 2 ( RS )  Lecture 5 – Teratogenesis part 1 ( RS )  Lecture 6 – Teratogenesis part 2 ( RS)

©Dr. Ron Saulnier HSS 4102 A Fall 2023 Evaluations Method(s) of evaluation Weight Due Date Compulsory? (note failure to complete a compulsory assessment will result in EIN) Midterm 25% Nov 1 st , 2023 Compulsory Infographic assignment 10% Oct 16 th , 2023 Compulsory Case Study assignment 25% Nov 13 th , 2023 Compulsory Final exam 40% TBA Compulsory

©Dr. Ron Saulnier HSS 4102 A Fall 2023 Midterm Midterm (25%) Nov 1 st , 2023 An in-class midterm containing a mix of multiple choice questions and short answer questions. Topics covered on the midterm will be drawn from class material (lecture material, classroom discussions, slides, videos, readings). The midterm will be held in class as scheduled and last the duration of the class period. Additional information on content and format will be provided 1 week prior to the midterm to help students prepare in their studying.

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©Dr. Ron Saulnier HSS 4102 A Fall 2023 Assignments Assignments (25%) + (10%) Both assignments 1 and 2 can be done in pairs however students can also do them as individuals. No groups of 3 or more. Case study assignment (worth 25% of final grade) A case study of a pregnant individual will be presented which contains several environmental factors which could alter the outcome of the pregnancy or the development of the fetus. Students will need to identify the environmental factors which can impact the pregnancy and the fetus as well as answer additional questions about the mechanisms and outcomes using both class notes and additional sources which they have researched. The assignment and additional instructions on how to complete it will be provided with the first couple of weeks of the term. The assignment can be done individually or in pairs and will be submitted through Brightspace. Feedback on the assignment will also be provided through Brightspace.

©Dr. Ron Saulnier HSS 4102 A Fall 2023 Infographic Assignment Infographic assignment (worth 10% of final grade) Infographics Infographics are graphic depictions of complex information (e.g., knowledge, data, concepts, ideas, etc.). This medium relies upon visual elements to clearly and concisely communicate complex information to diverse audiences. Infographics use evidence and practice-based data, compelling statistics, easy-to-read fonts, complimentary color schemes, simple charts, bold graphs, and other graphics to disseminate information in quick and easily digestible format. A list of suitable topics will be provided however other topics are possible with the professor’s permission. It is recommended that students use topics that are relevant to the course material. The assignment and additional instructions on how to complete it will be provided with the first couple of weeks of the term. The assignment can be done individually or in pairs and will be submitted through Brightspace. Feedback on the assignment will also be provided through Brightspace.

©Dr. Ron Saulnier HSS 4102 A Fall 2023 Infographic Assignment Infographics Infographics are graphic depictions of complex information (e.g., knowledge, data, concepts, ideas, etc.). This medium relies upon visual elements to clearly and concisely communicate complex information to diverse audiences. Infographics use evidence and practice-based data, compelling statistics, easy-to-read fonts, complimentary color schemes, simple charts, bold graphs, and other graphics to disseminate information in quick and easily digestible format. Working in pairs or individually, you will be required to prepare and submit a public health infographic assignment. A list of suitable topics will be provided however other topics are possible with the professor’s permission. It is recommended that students use topics that are relevant to the course material.

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©Dr. Ron Saulnier HSS 4102 A Fall 2023 Final Exam Final Exam (40% of final grade) The final exam will be in class and composed of a combination of multiple choice questions and short answer questions a from which you will need to answer questions related to the course material. The final exam is primarily on the material after the midterm, however, some concepts and terminology from the first part of the term may be required for complete answers. The Final exam has been scheduled as a 3 h exam. Additional information on content and format will be provided 1 week prior to the midterm to help students prepare in their studying.

©Dr. Ron Saulnier HSS 4102 A Fall 2023 Health Sciences Careers on the Rise http://www.publichealthonline.org/health-sciences/#context/api/listings/prefilter 20

©Dr. Ron Saulnier HSS 4102 A Fall 2023 Health Science jobs after graduation Professional • Medicine • Dentistry • Physiotherapy • Occupational therapy • Audiology • Speech language therapy • Law • Nursing • Osteopathy • Chiropractor • Optometrist • School Teacher Government • Project officer\Epidemiologist\Statistical assistant • Executive assistant • Policy analyst at PHAC

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©Dr. Ron Saulnier HSS 4102 A Fall 2023 Health Science jobs after graduation Other • Quality coordinator in a hospital • Disability case manager – for Canada life Insurance • Global regulatory affairs – Amgen pharmaceuticals • Health and safety coordinator – school board • Senior advisor, disability management and occupational health and safety at CIHR • Health promoter, healthy living division – York region • Health promotion specialist • Service analyst – child welfare • Clinical research coordinator – hospital foundations • Project officer International Federation on ageing • Infection prevention and control Manager – Revera

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©Dr. Ron Saulnier HSS 4102 A Fall 2023 Health Science jobs after graduation • Program manager – vascular cures • Canada Border services agency • Consumer and physician Relations at Innoneo Health systems • Team assistant- Central Local Health Integration Network - Champlain local health integration network (LHIN) • Clinical research coordinator at hospitals • Research coordinator at Better Outcomes Registry and Network (BORN) Ontario • Associate director- BMS Canada Risk Services • Health Information system specialists - hospital • Health Economics and market assess consultant – Amaris • Administrative strategy management resident – Mackenzie Health • Senior administrator, development and rehabilitation – CHEO

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©Dr. Ron Saulnier HSS 4102 A Fall 2023 Health Science jobs after graduation • Senior ATOP analyst at DND • Research assistant – Ottawa Heart Institute • Project manager – Autism Ontario • Senior corporate regulatory compliance and enforcement advisor – health Canada • Director, Health Promotion at The Heart and Stroke Foundation of New Brunswick • Business Advisor at Public Services and Procurement Canada • Associate consultant – Slalom • Associate medtech – Clarivate • Consultant – at IQUIA • Consultant – United Nations Population Fund (UNFP) - WHO • Teledoc • Telehealth • Senior client operations associate-maple

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