Sim 3 – Neural Simulation Graphs - Rickey Maung

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Skyline College *

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260

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Biology

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Apr 3, 2024

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BIOL 260 – Human Physiology PhysioEx 9 Neurophysiology Simulation Graphs A) Eliciting Neural Impulses – AP Neuro Sim #3 AP- Threshold Settings: 1) electrical stimulus intensity = 10, 20, 30, 40, 50 mV 2) stimulus location: axon of neuron 3) stimulus distances: stimulus to R1 = 2cm, R1 to R2 = 2 cm response: action potential 1) Effects of increasing stimulus intensity on neural response (PEx) 5 graphs: x=time (msec), y=stimulus (mV), voltage R2 & R1 (μV) Analysis: 1) Is there a response at 10 mV: No. 2) What was the size of the AP at different stimulation intensity: 100 microvolts 3) What was the time of the 2 AP at different stimulation intensity: 3.5 ms and 5.5 ms B) Inhibiting Neural Impulses Neuro Sim #4 – AP – Voltage-Gated Na + Channels Settings: 1) single stimulus: no drugs 2) multiple stimuli: no drug, ttx, lidocaine response: inhibition of AP 1) Effects of anesthetics on inhibiting AP (PEx) 3 graphs: x=time (sec), y=stimulus (mV), voltage R2 & R1 (μV) Analysis: 1) At what time did the inhibition occur after the following addition, if any: a) no drug: No inhibition b) ttx: 6 ms for R2 c) lidocaine: 8 ms for R2
C) Nerve Conduction Velocity Neuro Sim #7 – AP – Conduction Velocity settings: electrical stimulation of 3 fibers response: different conduction velocity of 3 fibers 1) Effects of stimulation on 3 fibers (PEx) 3 graphs: x=time (msec) y=stimulus (mV), voltage R2 & R1 (μV) Analysis: Attach the appropriate graph on each Description of each fiber; what are the diameter and the type of myelination. Encircle your answer. What is the speed of the AP potential on each fiber? Fill in the correct answer. Attach the appropriate graph for each fiber. (PEx) A Fiber: diameter & myelination - ( Thickest , medium, thinnest) fiber - ( Thickest , thin, none) myelin A Fiber: speed of AP - 1 st AP @ 3.5 ms - 2 nd AP @ 5.5 ms - Is this the fastest , 2 nd fastest or the slowest among the three fibers? B Fiber: diameter & myelination - (Thickest, medium , thinnest) fiber - (Thickest, thin , none) myelin B Fiber: speed of AP - 1 st AP @ 20 ms - 2 nd AP @ 30 ms - Is this the fastest, 2 nd fastest or the slowest among the three fibers? C Fiber: diameter & myelination - (Thickest, medium, thinnest ) fiber - (Thickest, thin, none ) myelin C Fiber: speed of AP - 1 st AP @ 150 ms - 2 nd AP @ 250 ms - Is this the fastest, 2 nd fastest or the slowest among the three fibers?
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