Concepts of Genetics (11th Edition)
11th Edition
ISBN: 9780321948915
Author: William S. Klug, Michael R. Cummings, Charlotte A. Spencer, Michael A. Palladino
Publisher: PEARSON
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Chapter ST.4, Problem 1RQ
What is pharmacogenomics, and how does it differ from pharmacogenetics?
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. Consider a base substitution mutation that occurred in a DNA sequence that resulted in a change in the
encoded protein from the amino acid glutamic acid to aspartic acid. Normally the glutamic acid amino acid
is located on the outside of the soluble protein but not near an active site.
O-H¨
A. What type of mutation occurred?
O-H
B. What 2 types of chemical bonds are found in the R-groups
of each amino acid? The R groups are shaded.
CH2
CH2
CH2
H2N-C-COOH
H2N-C-COOH
1
H
Glutamic acid
H
Aspartic acid
C. What 2 types of bonds could each R-group of each of these amino acids form with other molecules?
D. Consider the chemical properties of the two amino acids and the location of the amino acid in the
protein. Explain what effect this mutation will have on this protein's function and why.
engineered constructs that consist of hollow fibers are acting as synthetic capillaries, around which cells have been loaded. The cellular space around a single fiber can be modeled as if it were a Krogh tissue cylinder. Each fiber has an outside “capillary” radius of 100 µm and the “tissue” radius can be taken as 200 µm. The following values apply to the device:R0 = 20 µM/secaO2 = 1.35 µM/mmHgDO2,T = 1.67 x 10-5 cm2/secPO2,m = 4 x 10-3 cm/secInstead of blood inside the fibers, the oxygen transport and tissue consumption are being investigated by usingan aqueous solution saturated with pure oxygen. As a result, there is no mass transfer resistance in the synthetic“capillary”, only that due to the membrane itself. Rather than accounting for pO2 variations along the length ofthe fiber, use an average value in the “capillary” of 130 mmHg.Is the tissue fully oxygenated?
Molecular Biology
Please help with question. thank you
You are studying the expression of the lac operon. You have isolated mutants as described below. In the presence of glucose, explain/describe what would happen, for each mutant, to the expression of the lac operon when you add lactose AND what would happen when the bacteria has used up all of the lactose (if the mutant is able to use lactose).5. Mutations in the lac operator that strengthen the binding of the lac repressor 200 fold
6. Mutations in the promoter that prevent binding of RNA polymerase
7. Mutations in CRP/CAP protein that prevent binding of cAMP8. Mutations in sigma factor that prevent binding of sigma to core RNA polymerase
Chapter ST Solutions
Concepts of Genetics (11th Edition)
Ch. ST.1 - Prob. 1RQCh. ST.1 - Prob. 2RQCh. ST.1 - Prob. 3RQCh. ST.1 - Prob. 4RQCh. ST.1 - Prob. 5RQCh. ST.1 - Prob. 6RQCh. ST.1 - Prob. 7RQCh. ST.1 - How do microRNAs regulate epigenetic mechanisms...Ch. ST.1 - Prob. 9RQCh. ST.1 -
Imprinting disorders do not involve changes in...
Ch. ST.1 - Prob. 2DQCh. ST.1 - Prob. 3DQCh. ST.1 - Prob. 4DQCh. ST.2 - Prob. 1RQCh. ST.2 - Prob. 2RQCh. ST.2 - Prob. 3RQCh. ST.2 - Prob. 4RQCh. ST.2 - What are the three types of small noncoding RNAs...Ch. ST.2 - The mechanism for RNA-induced transcriptional...Ch. ST.2 - Prob. 7RQCh. ST.2 - Prob. 8RQCh. ST.2 - How and why are eukaryotic mRNAs transported and...Ch. ST.2 - The RNA World Hypothesis suggests that the...Ch. ST.2 - Prob. 2DQCh. ST.2 - Prob. 3DQCh. ST.2 - Prob. 4DQCh. ST.3 - What is VNTR profiling, and what are the...Ch. ST.3 - Prob. 2RQCh. ST.3 - Describe capillary electrophoresis. How does this...Ch. ST.3 - What are the advantages and limitations of...Ch. ST.3 - Prob. 5RQCh. ST.3 - Explain why mitochondrial DNA profiling is often...Ch. ST.3 - Prob. 7RQCh. ST.3 - Describe the database system known as CODIS. What...Ch. ST.3 - Prob. 9RQCh. ST.3 - Prob. 10RQCh. ST.3 - Given the possibility that synthetic DNA could be...Ch. ST.3 - Prob. 2DQCh. ST.3 - If you were acting as a defense lawyer in a murder...Ch. ST.3 - The phenomena of somatic mosaicism and chimerism...Ch. ST.4 - What is pharmacogenomics, and how does it differ...Ch. ST.4 - Describe how the drug Herceptin works. What types...Ch. ST.4 - Prob. 3RQCh. ST.4 - Prob. 4RQCh. ST.4 - Prob. 5RQCh. ST.4 - Prob. 6RQCh. ST.4 - Why is it necessary to examine gene-expression...Ch. ST.4 - Prob. 8RQCh. ST.4 - In this chapter, we present three case studies...Ch. ST.4 - Prob. 2DQCh. ST.4 - How can we ensure that a patients privacy is...Ch. ST.4 - As gene tests and genomic sequences become more...Ch. ST.5 - How do genetically modified organisms compare with...Ch. ST.5 - Prob. 2RQCh. ST.5 - Prob. 3RQCh. ST.5 - Prob. 4RQCh. ST.5 - Describe the mechanisms by which the Cry proteins...Ch. ST.5 - Prob. 6RQCh. ST.5 - Prob. 7RQCh. ST.5 - Describe how plants can be transformed using...Ch. ST.5 - How do positive and negative selection techniques...Ch. ST.5 - Prob. 10RQCh. ST.5 - What are the laws regulating the development,...Ch. ST.5 - Do you think that foods containing GM ingredients...Ch. ST.5 - Prob. 3DQCh. ST.6 - What is gene therapy?Ch. ST.6 - Prob. 2RQCh. ST.6 - When treating a person by gene therapy, is it...Ch. ST.6 - Describe two ways that therapeutic genes can be...Ch. ST.6 - Explain how viral vectors can be used for gene...Ch. ST.6 - Prob. 6RQCh. ST.6 - Explain an example of a successful gene therapy...Ch. ST.6 - Prob. 8RQCh. ST.6 - Prob. 9RQCh. ST.6 - Prob. 10RQCh. ST.6 - Prob. 1DQCh. ST.6 - Who should be treated by gene therapy? What...Ch. ST.6 - Prob. 3DQ
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- Molecular Biology Please help with question. Thank you You are studying the expression of the lac operon. You have isolated mutants as described below. In the absence of glucose, explain/describe what would happen, for each mutant, to the expression of the lac operon when you add lactose AND what would happen when the bacteria has used up all of the lactose (if the mutant is able to use lactose).1. Mutations in the lac repressor gene that would prevent the binding of lactose2. Mutations in the lac repressor gene that would prevent release of lactose once lactose hadbound3. Normally the lac repressor gene is located next to (a few hundred base pairs) and upstreamfrom the lac operon. Mutations in the lac repressor gene that move the lac repressor gene 100,000base pairs downstream.4. Mutations in the lac operator that would prevent binding of lac repressorarrow_forwardYou have returned to college to become a phylogeneticist. One of the first things you wish to do is determine how mammals, birds, and reptiles are related. Like any good scientist, you need to consider all available data objectively and without a preconceived “correct” answer. In pursuit of that, you should produce a phylogenetic tree based only on morphological features that show birds and mammals are more closely related. You will then produce a totally different tree, also using morphological features, that shows birds and reptiles are more closely related. Do not forget to include all three groups in both your trees. Based solely off the trees you produce, which relationship would you consider the more likely and why? Once you have answered that question, provide a brief summary of the “modern” understanding of the relationship between these three groups.arrow_forwardtrue or false, the reason geckos can walk on walls is hydrogen bonding between their foot pads and the moisture on the wall.arrow_forward
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