Concept explainers
Analyzing Journal Article Results Researchers (Brian G. Feagan et al. “Erythropoietin with Iron Supplementation to Prevent Allogeneic Blood Transfusion in Total Hip Joint Arthroplasty,” Annals of Internal Medicine, Vol. 133, No. 11) wanted to determine whether epoetin alfa was effective in increasing the hemoglobin concentration in patients undergoing hip arthroplasty. A complete medical history and physical of the patients was performed for screening purposes and eligible patients were identified. The researchers used a computer-generated schedule to assign the patients to the high-dose epoetin group, low-dose epoetin group, or placebo group. The study was double-blind. Based on ANOVA, it was determined that there were significant differences in the increase in hemoglobin concentration in the three groups with a P-value less than 0.001. The mean increase in hemoglobin in the high-dose epoetin group was 19.5 grams per liter (g/L), the mean increase in hemoglobin in the low-dose epoetin group was 17.2 g/L, and mean increase in hemoglobin in the placebo group was 1.2 g/L.
- (a) Why do you think it was necessary to screen patients for eligibility?
- (b) Why was a computer-generated schedule used to assign patients to the various treatment groups?
- (c) What does it mean for a study to be double-blind? Why do you think the researchers desired a double-blind study?
- (d) Interpret the reported P-value.
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Fundamentals of Statistics (5th Edition)
- Grey-Seal Nursing. Grey seals are one of several types of earless seals. The length of time that a female grey seal nurses her pup is studied by S. Twiss et al. in the article “Variation in Female Grey Seal (Halichoerus grypus) Reproductive Performance Correlates to Proactive-Reactive Behavioural Types” (PLOS ONE 7(11): e49598. doi:10.1371/journal.pone.0049598). The average lactation (nursing) period of all earless seals is 23 days. A hypothesis test is to be performed to decide whether the mean lactation period of grey seals differs from 23 days. a. determine the null hypothesis. b. determine the alternative hypothesis. c. classify the hypothesis test as two tailed, left tailed, or right tailed.arrow_forwardNCI Cancer Bulletin, December 2, 2008 Volume 5 / Number 24 Title of the article: After Menopause, Weight Affects Breast Cancer Rates More than Mammography Use Women who are overweight or obese after menopause face an increased risk of breast cancer, but a large prospective cohort study indicates that the frequency of mammography use and screening accuracy are not the primary explanations for higher rates of breast cancer in these women. The same is true of large, invasive breast cancer tumors and advanced stage disease; risk increases with weight, but higher rates are not explained by the frequency or accuracy of screening mammography before breast cancer was diagnosed. The study appears in the December 3 Journal of the National Cancer Institute. Dr. Karla Kerlikowske of the San Francisco Veterans Affairs Medical Center and colleagues gathered data on 287,115 postmenopausal women who were registered in the Breast Cancer Surveillance Consortium database. Reflecting a trend in the…arrow_forwardIn a study conducted in the Science Department of Faculty of Science, Technology and Human Development in a University; the researcher examined the influence of the drug succinylcholine on the circulation levels of androgens in the blood. Blood samples from wild, free-ranging deer were obtained via the jugular vein immediately after an intramuscular injection of succinylcholine using darts and a capture gun. Deer were bled again approximately 30 minutes after the injection and then released. The level of androgens at time of capture and 30 minutes later, measured in nanograms per milliliter (ng/ml), for 15 deers as in Table Q1. Assuming that the populations of androgen at time of injection and 30 minutes later are normally distributed:i) Find the average and standard deviation of this studyii)Determine the critical region of this problem.iii) Test at the 0.05 level of significance whether the androgen concentrations are altered after 30 minutes of restraint.arrow_forward
- NCI Cancer Bulletin, December 2, 2008 Volume 5 / Number 24 Title of the article: After Menopause, Weight Affects Breast Cancer Rates More than Mammography Use Women who are overweight or obese after menopause face an increased risk of breast cancer, but a large prospective cohort study indicates that the frequency of mammography use and screening accuracy are not the primary explanations for higher rates of breast cancer in these women. The same is true of large, invasive breast cancer tumors and advanced stage disease; risk increases with weight, but higher rates are not explained by the frequency or accuracy of screening mammography before breast cancer was diagnosed. The study appears in the December 3 Journal of the National Cancer Institute. Dr. Karla Kerlikowske of the San Francisco Veterans Affairs Medical Center and colleagues gathered data on 287,115 postmenopausal women who were registered in the Breast Cancer Surveillance Consortium database. Reflecting a trend in the…arrow_forwardNCI Cancer Bulletin, December 2, 2008 Volume 5 / Number 24 Title of the article: After Menopause, Weight Affects Breast Cancer Rates More than Mammography Use Women who are overweight or obese after menopause face an increased risk of breast cancer, but a large prospective cohort study indicates that the frequency of mammography use and screening accuracy are not the primary explanations for higher rates of breast cancer in these women. The same is true of large, invasive breast cancer tumors and advanced stage disease; risk increases with weight, but higher rates are not explained by the frequency or accuracy of screening mammography before breast cancer was diagnosed. The study appears in the December 3 Journal of the National Cancer Institute. Dr. Karla Kerlikowske of the San Francisco Veterans Affairs Medical Center and colleagues gathered data on 287,115 postmenopausal women who were registered in the Breast Cancer Surveillance Consortium database. Reflecting a trend in the…arrow_forwardNCI Cancer Bulletin, December 2, 2008 Volume 5 / Number 24 Title of the article: After Menopause, Weight Affects Breast Cancer Rates More than Mammography Use Women who are overweight or obese after menopause face an increased risk of breast cancer, but a large prospective cohort study indicates that the frequency of mammography use and screening accuracy are not the primary explanations for higher rates of breast cancer in these women. The same is true of large, invasive breast cancer tumors and advanced stage disease; risk increases with weight, but higher rates are not explained by the frequency or accuracy of screening mammography before breast cancer was diagnosed. The study appears in the December 3 Journal of the National Cancer Institute. Dr. Karla Kerlikowske of the San Francisco Veterans Affairs Medical Center and colleagues gathered data on 287,115 postmenopausal women who were registered in the Breast Cancer Surveillance Consortium database. Reflecting a trend in the…arrow_forward
- Low-Birth-Weight Hospital Stays. Data on low-birthweight babies were collected over a 2-year period by 14 participating centers of the National Institute of Child Health and Human Development Neonatal Research Network. Results were reported by J. Lemons et al. in the on-line paper “Very Low Birth Weight Outcomes of the National Institute of ChildHealth and Human Development Neonatal Research Network” (Pediatrics, Vol. 107, No. 1, p. e1). For the 1084 surviving babies whose birth weights were 751– 1000 grams, the average length of stay in the hospital was 86 days, although one center had an average of 66 days and another had an average of 108 days. a. Can the mean lengths of stay be considered population means? Explain your answer.b. Assuming that the population standard deviation is 12 days, determine the z-score for a baby’s length of stay of 86 days at the center where the mean was 66 days.c. Assuming that the population standard deviation is 12 days, determine the z-score for a…arrow_forwardA data set from a study that examined the effect of a specific diet on blood pressure is provided . Participants (n = 72) were randomly assigned either to a group that was put on the diet (Diet = Present) or to a group that was not put on the diet (Diet = Absent), and researchers wanted to know whether the diet had a significant impact on blood pressure. Fully interpret the results in the context of this study (i.e., report the conclusions as related to the research question).arrow_forwardA pathological video game user (PVGU) is a video game user that averages 31 or more hours a week of gameplay. According to the article “Pathological Video Game Use among Youths: A Two-Year Longitudinal Study” (Pediatrics, Vol. 127, No. 2, pp. 319–329) by D. Gentile et al., in 2011, about 9% of children in grades 3–8 were PVGUs. Suppose that, today, five youths in grades 3–8 are randomly selected. Let X represent the number of youths who are PVGUs. n = p = 1 – p = Prepare the probability distribution for the random variable X. Complete the following table. Round your answers to 4 decimal places e.g. 0.XXXX or .XXXX. X = x P(X=x) 0 1 2 3 4 5 ∑=1.0000∑=1.0000 Calculate the probability that EXACTLY three youths are PVGUs. Round your answers to 4 decimal places e.g. 0.XXXX or .XXXX. P(X = 3) = Calculate the probability that AT LEAST two youths are PVGUs. Round your answers to 4 decimal places e.g. 0.XXXX or .XXXX. P(X ≥ 2) = Calculate the…arrow_forward
- Elissa Epel, a professor of health psychology at the University of California–San Francisco, studied women in high- and low-stress situations. She found that women with higher cortisol responses to stress ate significantly more sweet food and consumed more calories on the stress day compared with those with low cortisol responses, and compared with themselves on lower stress days. Increases in negative mood in response to the stressors were also significantly related to greater food consumption. These results suggest that psychophysiological responses to stress may influence subsequent eating behavior. Over time, these alterations could impact both weight and health. You are interested in studying whether students living in the dorms or students living off campus have higher cortisol levels. You ask a sample of n₁ = 25 students living in the dorms and n₂ = 30 students living off campus to record their afternoon cortisol levels for a week. The average cortisol level for students living…arrow_forwardA study was made of 413 children who were hospitalized as a result of motor vehicle crashes. Among 290 children who were not using seat belts, 60 were injured severely. Among 123 children using seat belts, 16 were injured severely (based on data from "Morbidity Among Pediatric Motor Vehicle Crash Victims: The Effectiveness of Seat Belts," by Osberg and Di Scala, American Journal of Public Health, Vol. 82, No. 3). For this problem we want to know, is there sufficient sample evidence to conclude, at the 0.05 significance level, that the proportion of severe injuries is higher for children not wearing seat belts? Let pi be the proportion of severe injuries among all children not wearing seatbelts and who were involved in crashes. Let p2 be the proportion of severe injuries among all children wearing seatbelts and who were involved in crashes. Which is the proper expression of Ho? Pi = P2 O Pi P2 Which is the proper expression of H1? O pi P2 Calculate p1 to 4 decimal places: Calculate p,…arrow_forwardA study was conducted to examine the effect of diet cola consumption on calcium levels in women. A sample of 16 healthy women aged 18 to 40 were randomly assigned to drink 24 ounces of either diet cola or water. Their urine was collected for three hours after ingestion of the beverage and calcium excretion (in mg) was measured. The data are stored in ColaCalcium.arrow_forward
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