Concepts of Genetics (11th Edition)
11th Edition
ISBN: 9780321948915
Author: William S. Klug, Michael R. Cummings, Charlotte A. Spencer, Michael A. Palladino
Publisher: PEARSON
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Chapter 8, Problem 2PDQ
Review the Chapter Concepts list on page 171. These all center around chromosomal aberrations that create variations from the “normal” diploid genome. Write a short essay that discusses five altered
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Duchenne muscular dystrophy is an X-linked, recessive disorder in which muscles waste away early in life, resulting in death in the teens or twenties. A man and woman in their late thirties have five children—three boys (ages 1, 3, and 10 years) and two girls (ages 5 and 7 years). The oldest, boy shows symptoms of the disease. What are the probabilities that their other children will develop the disease?
Give only typing answer with explanation and conclusion
please answer both blanks
Concordance studies of twins for a neurodegenerative disorder show MZ=
46% and DZ= 15%. Further studies have shown a possible link to a gene
on chromosome 9, however, there are some individuals in the study who
have the allele but do not develop the disorder (group 1), and there are
other individuals who do not have the allele yet develop the disorder
(group 2). Amita's older sister and maternal uncle have this disorder.
Currently, Amita & her 2 younger brothers do not show symptoms. Amita's
paternal grandfather was rumored to have this disorder.
1. Draw the pedigree for Amita's family and determine the mode of
inheritance if any.
2. Explain how the 2 groups in the study could be possible?
3. What would you tell Amita about the heritability of this disorder?
Chapter 8 Solutions
Concepts of Genetics (11th Edition)
Ch. 8 - A human female with Turner syndrome (47, X) also...Ch. 8 - When two plants belonging to the same genus but...Ch. 8 - What is the effect of a rare double crossover (a)...Ch. 8 - Prob. 1CSCh. 8 - Prob. 2CSCh. 8 - Aquatic vegetation overgrowth, usually controlled...Ch. 8 - HOW DO WE KNOW? In this chapter, we have focused...Ch. 8 - Review the Chapter Concepts list on page 171....Ch. 8 - Define these pairs of terms, and distinguish...Ch. 8 - For a species with a diploid number of 18,...
Ch. 8 - What evidence suggests that Down syndrome is more...Ch. 8 - What evidence indicates that humans with aneuploid...Ch. 8 - Contrast the fertility of an allotetraploid with...Ch. 8 - Describe the origin of cultivated American cotton.Ch. 8 - Predict how the synaptic configurations of...Ch. 8 - Inversions are said to suppress crossing over. Is...Ch. 8 - Contrast the genetic composition of gametes...Ch. 8 - Human adult hemoglobin is a tetramer containing...Ch. 8 - Discuss Ohnos hypothesis on the role of gene...Ch. 8 - What roles have inversions and translocations...Ch. 8 - The primrose, Primula kewensis, has 36 chromosomes...Ch. 8 - Certain varieties of chrysanthemums contain 18,...Ch. 8 - Drosophila may be monosomic for chromosome 4, yet...Ch. 8 - Mendelian ratios are modified in crosses involving...Ch. 8 - Having correctly established the F2 ratio in...Ch. 8 - The mutations called bobbed in Drosophila result...Ch. 8 - The outcome of a single crossover between...Ch. 8 - A couple planning their family are aware that...Ch. 8 - In a cross in Drosophila, a female heterozygous...Ch. 8 - A woman who sought genetic counseling is found to...Ch. 8 - Prob. 25ESPCh. 8 - In a recent cytogenetic study on 1021 cases of...Ch. 8 - A boy with Klinefelter syndrome (47,XXY) is born...Ch. 8 - Prob. 28ESPCh. 8 - Prob. 29ESPCh. 8 - A 3-year-old child exhibited some early indication...Ch. 8 - A normal female is discovered with 45 chromosomes,...Ch. 8 - Prob. 32ESP
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- Describe the chromosomal alterations and phenotype of cri du chat syndrome and Prader-Willi syndrome.arrow_forwardTheodor Boveri predicted that malignancies would often be associated with chromosomal mutation. What lines of evidence substantiate this prediction?arrow_forwardConsider a Droscophilia fly with a genotype of Nn XqYY. The dominant allele of the sex-linked gene specifies a black body and the recessive a white body. The recessive autosomal allele specifies hairy bristles while the dominant allele specifies smooth bristles. i)What is the ploidy of this fly? ii) What would the sex of this fly be? iii)What would the phenotype of this fly be with respect to these two loci?arrow_forward
- During the pathoanatomic inspection of a baby-boy's dead body the following abnormalities: polydactily, microcephaly, a cleft lip and cleft palate, hypertrophy of the parenchymal organs were found. These symptoms are typical of Patau syndrome. What is the cause of this disease? Select one: a. Trisomy on the 21st chromosome. O b. Trisomy on the 18th chromosome. c. Trisomy on the 13th chromosome. d. Trisomy on X chromosome. e. Monosomy on X chromosome.arrow_forwardGive typed full explanationarrow_forwardA woman is affected with Prader-Willi syndrome due to a deletion that includes both the Angelman syndrome and Prader-Willi syndrome genes. Although rare, fertility among Prader-Willi syndrome individuals has been documented. For each of the following, state what is the probability of the outcome if she were to become pregnant. Assume the male partner in the pregnancy has no genetic disorder. A) a child with neither Prader-Willi syndrome or Angelman syndrome B) A child with AS C) A child with Prader-Willi syndromearrow_forward
- Question:- A) Give one domain.motif found in the SRY portion and state clearly how it leads to the development of the Wollfian system. B) Explain the genotype and the phenotype of an XY female and how such an individual could occur. C) Explain the genotype and the phenotype of an XX male and how such an individual could occur.arrow_forwardUniparental disomy (UPD) occurs when both chromosomes of a pair or areas from one chromosome in any individual have been inherited from a single parent. Since chromosomal numbers remain the same, cytogenetic analysis will not detect them. Hence, UPD disorders were not described until recently since molecular analysis is required to show that the two chromosomes originated from the same parent. Read recently published literature regarding UPD, and answer the following questions: What are the mechanisms that lead to UPD? Give at least 3 examples of UPD disorders and their clinical consequences: UPD Disorder OMIM # Locus Type of UPD Phenotype (include images) 1 2 3arrow_forwardDuchenne Muscular Dystrophy (DMD) is a disorder that primarily affects the function of skeletal muscles used for movement and cardiac muscles used for heart beating. Dystrophin is a protein encoded by a single gene, DMD, that is expressed in skeletal and cardiac muscle. Some forms of muscular dystrophy may be caused by different mutations in the DNA sequence of the DMD gene. Because the DMD locus is on the X chromosome, males are affected at higher rates. Two brothers, one of whom has DMD and one of whom does not, worked with their genetic counselor (Links to an external site.) to have their DMD gene sequenced to identify genetic variation that may explain why one brother was affected and the other not. Because DMD is a very long gene, a fictionalized, simplified model of the results is presented here (Figure 1). The actual DMD mRNA is about 16,000 base-pairs!------Consider single nucleotide polymorphism (SNP) #1 (Figure 1). Is this mutation likely to cause Duchenne muscular…arrow_forward
- The gene causing Coffin-Lowry syndrome (OMIM 303600) was recently identified and mapped on the human X chromosome. Coffin-Lowry syndrome is a rare disorder affecting brain morphology and development. It also produces skeletal and growth abnormalities, as well as abnormalities of motor control. Coffin-Lowry syndrome affects males who inherit a mutation of the X-linked gene. Most carrier females show no symptoms of the disease but a few carriers do. These carrier females are always less severely affected than males. Offer an explanation for this finding.arrow_forward7. please answer thisarrow_forwardDescribe the imbalance in gene products that occurs in an individual with monosomy 2.arrow_forward
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