Concepts of Genetics (11th Edition)
Concepts of Genetics (11th Edition)
11th Edition
ISBN: 9780321948915
Author: William S. Klug, Michael R. Cummings, Charlotte A. Spencer, Michael A. Palladino
Publisher: PEARSON
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Chapter 8, Problem 22PDQ

A couple planning their family are aware that through the past three generations on the husband’s side a substantial number of stillbirths have occurred and several malformed babies were born who died early in childhood. The wife has studied genetics and urges her husband to visit a genetic counseling clinic, where a complete karyotype-banding analysis is performed. Although the tests show that he has a normal complement of 46 chromosomes, banding analysis reveals that one member of the chromosome 1 pair (in group A) contains an inversion covering 70 percent of its length. The homolog of chromosome 1 and all other chromosomes show the normal banding sequence.

  1. (a) How would you explain the high incidence of past stillbirths?
  2. (b) What can you predict about the probability of abnormality/ normality of their future children?
  3. (c) Would you advise the woman that she will have to bring each pregnancy to term to determine whether the fetus is normal? If not, what else can you suggest?
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A couple planning their family are aware that through the pastthree generations on the husband’s side a substantial numberof stillbirths have occurred and several malformed babies wereborn who died early in childhood. The wife has studied geneticsand urges her husband to visit a genetic counseling clinic,where a complete karyotype-banding analysis is performed.Although the tests show that he has a normal complement of46 chromosomes, banding analysis reveals that one memberof the chromosome 1 pair (in group A) contains an inversioncovering 70 percent of its length. The homolog of chromosome1 and all other chromosomes show the normal bandingsequence. Question: What can you predict about the probability of abnormality/normality of their future children?
A couple planning their family are aware that through the pastthree generations on the husband’s side a substantial numberof stillbirths have occurred and several malformed babies wereborn who died early in childhood. The wife has studied geneticsand urges her husband to visit a genetic counseling clinic,where a complete karyotype-banding analysis is performed.Although the tests show that he has a normal complement of46 chromosomes, banding analysis reveals that one memberof the chromosome 1 pair (in group A) contains an inversioncovering 70 percent of its length. The homolog of chromosome1 and all other chromosomes show the normal bandingsequence. Question: How would you explain the high incidence of paststillbirths?
A couple planning their family are aware that through the past threegenerations on the husband's side a substantial number of stillbirthshave occurred and several malformed babies were born who diedearly in childhood. The wife has studies genetics and urges herhusband to visit a genetic counseling clinic, where a completekaryotype-banding analysis is performed. Although the tests showthat he has a normal complement of 46 chromosomes, bandinganalysis reveals that one member of the chromosome 1 pair (ingroup A) contains an inversion covering 70 percent of its length.The homolog of chromosome 1 and all other chromosomes showthe normal banding sequence.(a) How would you explain the high incidence of past stillbirths?predictabouttheprobabilityof(b) What can you  abnormality/normality of their future children?(c) Would you advise the woman that she will have to bring each pregnancy to term to determine whether the fetus is normal? Ifnot, what else can you suggest?

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Concepts of Genetics (11th Edition)

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