Fundamentals of Biostatistics
8th Edition
ISBN: 9781305268920
Author: Bernard Rosner
Publisher: Cengage Learning
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Chapter 8, Problem 19P
The drug diflunisal is used to treat mild to moderate pain due to osteoarthritis (OA) and rheumatoid arthritis (RA). The ocular effects of diflunisal had not been considered until a study was conducted on its effect on intraocular pressure in glaucoma patients who were already receiving maximum therapy for glaucoma [5].
Suppose the change (mean ± sd ) in intraocular pressure after administration of diflunisal (follow-up – baseline) among 10 patients whose standard therapy was methazolamide and topical glaucoma medications was −1.6 ± 1.5 mm Hg. Assess the statistical significance of the results.
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Does the potency of drug reduce after one year in storage?
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a.H0: μ1 - μ2 ≤ 0, Ha: μ1 - μ2 = 0
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Some people don't gain weight even when they overeat. Perhaps fidgeting and other “nonexercise activity"
(NEA) explains why – the body might spontaneously increase nonexercise activity when fed more. Researchers
deliberately overfed 16 healthy young adults for 8 weeks. They measured fat gain (y, in kilograms) and increase
in energy use (NEA) (x, in calories), as an explanatory variable, from activity other than deliberated exercise –
fidgeting, daily living, and the like. Here are the data (sorted by NEA):
NEA increase
-94
-57
-29 135
143
151
245 355
620 690
Fat gain
4.2
3.0
3.7 2.7
3.2
3.6
2.4
1.3
2.3
1.1
Assume that the model Fat gain= Bo +B,NEA increase +ɛ is reasonable. Selected SAS output are given here.
0.73985 R-Square 0.6061
2.38750 Adj R-Sq 0.5780
Root MSE
Dependent Mean
Coeff Var
30.98860
Parameter Estimates
Variable
DF
Parameter Estimate
Standard Error
t Value
Pr > It|
Intercept
1
3.50512
0.30362
11.54
<.0001
1
-0.00344
0.00074141
-4.64
0.0004
nea
(a) Find the average fat…
The average value of the residuals is
Chapter 8 Solutions
Fundamentals of Biostatistics
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Ch. 8 - The mean 1 sd of ln [calcium intake (mg)] among 25...Ch. 8 - The mean 1 sd of ln [calcium intake (mg)] among 25...Ch. 8 - The mean 1 sd of ln [calcium intake (mg)] among 25...Ch. 8 - Refer to the data in Table 2.13. Table 2.13...Ch. 8 - Refer to the data in Table 2.13. What is the...Ch. 8 - Refer to the data in Table 2.13. Perform the...Ch. 8 - Refer to the data in Table 2.13. What is the...Ch. 8 - Refer to the data in Table 2.13. 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