Fundamentals of Biostatistics
8th Edition
ISBN: 9781305268920
Author: Bernard Rosner
Publisher: Cengage Learning
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Chapter 8, Problem 20P
The drug diflunisal is used to treat mild to moderate pain due to osteoarthritis (OA) and rheumatoid arthritis (RA). The ocular effects of diflunisal had not been considered until a study was conducted on its effect on intraocular pressure in glaucoma patients who were already receiving maximum therapy for glaucoma [5].
The change in intraocular pressure after administration of diflunisal among 30 patients whose standard therapy was topical drugs only was −0.7 ± 2.1 mm Hg. Assess the statistical significance of these results.
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Captopril is a drug designed to lower systolic blood pressure. When subjects were treated with this drug, their systolic blood pressure readings (in mm Hg) were measured before and after the drug was taken. Results are given in the accompanying table (based on data from "Essential Hypertension: Effect of an Oral Inhibitor of Angiotensin-Converting Enzyme," by MacGregor et al., British Medical Journal, Vol. 2).
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Chapter 8 Solutions
Fundamentals of Biostatistics
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