Chapter 8, Problem 12P

A particular protein has the amino acid sequence

N…Ala-Pro-His-Trp-Arg-Lys-Gly-Val-Thr …C within its primary structure. A geneticist studying mutations affecting this protein discovered that several of the mutants produced shortened protein molecules that terminated within this region. In one of them, the His became the terminal amino acid.

a.	What DNA single-base change(s) would cause the protein to terminate at the His residue?
b.	What other potential sites do you see in the DNA sequence encoding this protein where mutation of a single base pair would cause premature termination of translation?