Brock Biology of Microorganisms (15th Edition)
15th Edition
ISBN: 9780134261928
Author: Michael T. Madigan, Kelly S. Bender, Daniel H. Buckley, W. Matthew Sattley, David A. Stahl
Publisher: PEARSON
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Chapter 7, Problem 2AQ
Explain how cells exhibiting different
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Use the picture below to answer the questions that follow.
A
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Which of letters indicate:
1) identical molecules of DNA [Select]
B
2) similar molecules of DNA, can have different alleles [Select]
3) the result of S phase [Select]
4) Do the two chromosomes (red and blue) have the same genes?
[Select]
Suppose that you are studying the role of Protein B, which you believe plays a role in regulating PCD/Apoptosis in mice. You create two lines of mutant mice. One (bb) is homozygous for a loss-of-function allele of gene B. The other (Bb) is heterozygous, with one wild-type allele and one loss-of function allele. Initially you pay particular attention to two phenotypes of the resulting mice:(i) The morphology of their paws (see picture) (ii) The size of their brains & shape of their skulls. The bb mice have unusually large brains and unusual protrusions from their skulls. Based on these data, does it appear that Protein B, when present and active, favors or inhibits PCD/Apoptosis?Briefly explain your reasoning. The answer should address both the paw and brain/skull data.
Suppose that you are studying the role of Protein B, which you believe plays a role in regulating PCD/Apoptosis in mice. You create two lines of mutant mice. One (bb) is homozygous for a loss-of-function allele of gene B. The other (Bb) is heterozygous, with one wild-type allele and one loss-of function allele. Initially you pay particular attention to two phenotypes of the resulting mice:(i) The morphology of their paws (see picture)(ii) The size of their brains & shape of their skulls. The bb mice have unusually large brains and unusual protrusions from their skulls.
Suggest one other aspect of mouse morphology or physiology that you might expect to be altered in the absence of Protein B. Briefly explain your reasoning.
Also, based on the apparent effect of Protein B on the likelihood of PCD/Apoptosis, would you classify Protein B as the product of a proto-oncogene or of a tumor suppressor gene?
Chapter 7 Solutions
Brock Biology of Microorganisms (15th Edition)
Ch. 7.1 - What is the utility of a reporter gene?Ch. 7.1 - Prob. 2MQCh. 7.1 - Prob. 1CRCh. 7.2 - Prob. 1MQCh. 7.2 - Prob. 2MQCh. 7.2 - Prob. 1CRCh. 7.3 - What is the divisome?Ch. 7.3 - How does FtsZ find the cell midpoint of a...Ch. 7.3 - What is the role of the penicillin-binding protein...Ch. 7.4 - How does MreB control the shape of a rod-shaped...
Ch. 7.4 - What protein is thought to control the shape of...Ch. 7.4 - What relationships exist between cytoskeletal...Ch. 7.4 - What morphology do cells have that lack MreB or...Ch. 7.5 - Prob. 1MQCh. 7.5 - What is transpeptidation and why is it important...Ch. 7.5 - Prob. 1CRCh. 7.6 - How are different sets of genes expressed in the...Ch. 7.6 - Prob. 2MQCh. 7.6 - Prob. 1CRCh. 7.7 - Why are the levels of DnaA protein controlled...Ch. 7.7 - Prob. 2MQCh. 7.7 - Prob. 1CRCh. 7.8 - Prob. 1MQCh. 7.8 - What is the major transcriptional regulator that...Ch. 7.8 - What is meant by "patterning" during heterocyst...Ch. 7.9 - What are the four basic stages of biofilm...Ch. 7.9 - Besides autoinducer synthesis, what intracellular...Ch. 7.9 - What type of genes does c-di-GMP activate during...Ch. 7.10 - Describe two targets of antibiotics and discuss...Ch. 7.10 - Prob. 2MQCh. 7.10 - Prob. 3MQCh. 7.10 - Prob. 1CRCh. 7.11 - Is persistence a heritable trait?Ch. 7.11 - What prevents the toxin component of TA modules...Ch. 7.11 - Prob. 3MQCh. 7.11 - Prob. 1CRCh. 7 - If DnaA was not regulated in Escherichia coli and...Ch. 7 - Explain how cells exhibiting different phenotypes...Ch. 7 - Describe how you would genetically design a...
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