The reason behind the less dangerous effect of taking large quantities of valium than taking large quantities of phenobarbital. Concept introduction: A target site is the site to which the target molecule binds. The target molecule can be a hormone or a neurotransmitter. The target molecule discussed here is the GABA (gamma-aminobutyric acid), which is an inhibitory neurotransmitter. Phenobarbital and valium are depressants of the central nervous system. Phenobarbital is an orthosteric drug that binds to the target site of the receptor. Valium is a derivative of the chemical compound called benzodiazepine, and is an allosteric drug. An allosteric drug binds at the allosteric site of the receptor, which is other than the active site, whereas phenobarbital binds to the target site.

Question

At a pH equal to the isoelectric point (pl) of alanine, the net charge of alanine is zero. Two structures can be drawn that have a net charge of zero, but the predominant form of alanine at its pl is zwitterionic. CH3 H,N CH3 ** H¸N-C H Zwitterionic H Uncharged OH Select statements that explain why alanine is predominantly zwitterionic at its pl. pk of alanine's amino group is more than its pl. pk of alanine's carboxyl group is more than its pl. PK of alanine's carboxyl group is less than its pl. pk of alanine's amino group is less than its pl. Correct Answer What fraction of alanine is in the completely uncharged form at its pl? 1 in 2.2 × 107 1 in 1.6 × 10² 1 in 4680 1 in 9460

Answer 1

Question

Chapter 7, Problem 23RE

Interpretation Introduction

Interpretation:

The reason behind the less dangerous effect of taking large quantities of valium than taking large quantities of phenobarbital.

Concept introduction:

A target site is the site to which the target molecule binds. The target molecule can be a hormone or a neurotransmitter. The target molecule discussed here is the GABA (gamma-aminobutyric acid), which is an inhibitory neurotransmitter.

Phenobarbital and valium are depressants of the central nervous system. Phenobarbital is an orthosteric drug that binds to the target site of the receptor. Valium is a derivative of the chemical compound called benzodiazepine, and is an allosteric drug. An allosteric drug binds at the allosteric site of the receptor, which is other than the active site, whereas phenobarbital binds to the target site.

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At a pH equal to the isoelectric point (pl) of alanine, the net charge of alanine is zero. Two structures can be drawn that have a net charge of zero, but the predominant form of alanine at its pl is zwitterionic. CH3 H,N CH3 ** H¸N-C H Zwitterionic H Uncharged OH Select statements that explain why alanine is predominantly zwitterionic at its pl. pk of alanine's amino group is more than its pl. pk of alanine's carboxyl group is more than its pl. PK of alanine's carboxyl group is less than its pl. pk of alanine's amino group is less than its pl. Correct Answer What fraction of alanine is in the completely uncharged form at its pl? 1 in 2.2 × 107 1 in 1.6 × 10² 1 in 4680 1 in 9460

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