BIOCHEMISTRY (LOOSELEAF) >CUSTOM PKG<
8th Edition
ISBN: 9781305760738
Author: Campbell
Publisher: CENGAGE C
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Textbook Question
Chapter 7, Problem 1RE
RECALL What features distinguish enzymes that undergo allosteric control from those that obey the Michaelis–Menten equation?
Expert Solution & Answer
Interpretation Introduction
Interpretation:
The difference between the enzymes that undergo allosteric control and the ones that obey the Michaelis–Menten equation is to be discussed.
Concept introduction:
The allosteric enzymes have multiple sites called allosteric sites. These enzymes change their shape when they bind to the substrate.
The binding of a molecule other than that of the substrate molecule can cause hindrance in the activity of the enzyme.
Answer to Problem 1RE
Solution:
The allosteric enzymes have multiple subunits and allosteric sites, whereas the Michaelis–Menten enzymes have a single active site, so there is a difference between the activities of these two enzymes. The rate of the concentration and substrate concentration graph for the allosteric enzyme is sigmoidal, while for the Michaelis–Menten enzyme, it is hyperbolic.
Explanation of Solution
The differences between the enzyme that undergo allosteric control and the ones that follow Michaelis–Menten equation are given in the table below:
| Allosteric enzyme | Michaelis-Menten enzyme |
| The allosteric enzymes have a number of allosteric sites or active sites. | These enzymes have a single active site to which a particular substrate can bind. |
| The multiple sites show the property of cooperativity, which means the binding of one molecule facilitates the binding of another molecule. | The substrate binds to the active site of the enzyme and leads to the formation of products. |
| The allosteric enzymes exist in two states: R-state and T-state. | The enzymes exist in a single native form only. |
| These enzymes show sigmoidal curve in the graph of reaction rate versus substrate concentration. | The enzymes show hyperbolic curve in the rate of the reaction versus substrate concentration graph. |
Conclusion
Hence, it can be concluded that the allosteric enzymes are unique as compared to the other enzymes because of their capability of adaptation to various conditions in the environment and are much different from the enzymes that follow Michaelis–Menten equation.
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Chapter 7 Solutions
BIOCHEMISTRY (LOOSELEAF) >CUSTOM PKG<
Ch. 7 - RECALL What features distinguish enzymes that...Ch. 7 - RECALL What is the metabolic role of aspartate...Ch. 7 - RECALL What molecule acts as a positive effector...Ch. 7 - RECALL Is the term KM used with allosteric...Ch. 7 - Prob. 5RECh. 7 - Prob. 6RECh. 7 - RECALL What is a homotropic effect? What is a...Ch. 7 - RECALL What is the structure of ATCase?Ch. 7 - RECALL How is the cooperative behavior of...Ch. 7 - RECALL Does the behavior of allosteric enzymes...
Ch. 7 - RECALL Does the behavior of allosteric enzymes...Ch. 7 - RECALL Explain what is meant by K0.5.Ch. 7 - REFLECT AND APPLY Explain the experiment used to...Ch. 7 - RECALL Distinguish between the concerted and...Ch. 7 - RECALL Which allosteric model can explain negative...Ch. 7 - RECALL With the concerted model, what conditions...Ch. 7 - Prob. 17RECh. 7 - Prob. 18RECh. 7 - Prob. 19RECh. 7 - Prob. 20RECh. 7 - Prob. 21RECh. 7 - BIOCHEMICAL CONNECTIONS How does Valium work?Ch. 7 - Prob. 23RECh. 7 - Prob. 24RECh. 7 - RECALL What is the function of a protein kinase?Ch. 7 - RECALL What amino acids are often phosphorylated...Ch. 7 - REFLECT AND APPLY What are some possible...Ch. 7 - REFLECT AND APPLY Explain how phosphorylation is...Ch. 7 - REFLECT AND APPLY Explain how glycogen...Ch. 7 - Prob. 30RECh. 7 - Prob. 31RECh. 7 - RECALL Name three proteins that are subject to the...Ch. 7 - Prob. 33RECh. 7 - RECALL What are caspases?Ch. 7 - REFLECT AND APPLY Explain why cleavage of the bond...Ch. 7 - REFLECT AND APPLY Why is it necessary or...Ch. 7 - Prob. 37RECh. 7 - Prob. 38RECh. 7 - Prob. 39RECh. 7 - RECALL What are the two essential amino acids in...Ch. 7 - RECALL Why does the enzyme reaction for...Ch. 7 - REFLECT AND APPLY Briefly describe the role of...Ch. 7 - REFLECT AND APPLY Explain the function of...Ch. 7 - REFLECT AND APPLY Explain why the second phase of...Ch. 7 - Prob. 45RECh. 7 - REFLECT AND APPLY An inhibitor that specifically...Ch. 7 - REFLECT AND APPLY What properties of metal ions...Ch. 7 - RECALL In biochemistry mechanisms, what group is...Ch. 7 - Prob. 49RECh. 7 - REFLECT AND APPLY Explain the difference between...Ch. 7 - Prob. 51RECh. 7 - Prob. 52RECh. 7 - Prob. 53RECh. 7 - REFLECT AND APPLY What is the relationship between...Ch. 7 - Prob. 55RECh. 7 - BIOCHEMICAL CONNECTIONS Why can cocaine addiction...Ch. 7 - Prob. 57RECh. 7 - Prob. 58RECh. 7 - RECALL How are coenzymes related to vitamins?Ch. 7 - RECALL What type of reaction uses vitamin B6?Ch. 7 - Prob. 61RECh. 7 - Prob. 62RECh. 7 - Prob. 63RECh. 7 - BIOCHEMICAL CONNECTIONS What are some of the ways...
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