Genetics: From Genes to Genomes, 5th edition
Genetics: From Genes to Genomes, 5th edition
5th Edition
ISBN: 9780073525310
Author: Leland H. Hartwell, Michael L. Goldberg, Janice A. Fischer, Leroy Hood, Charles F. Aquadro
Publisher: McGraw-Hill Education
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Chapter 6, Problem 18P

If you expose human tissue culture cells (for example, HeLa cells) to 3H-thymidine just as they enter S phase, then wash this material off the cells and let them go through a second S phase before looking at the chromosomes, how would you expect the 3H to be distributed over a pair of homologous chromosomes? (Ignore the effect recombination could have on this outcome.) Would the radioactivity be in (a) one chromatid of one homolog, (b) both chromatids of one homolog, (c) one chromatid each of both homologs, (d) both chromatids of both homologs, or (e) some other pattern? Choose the correct answer and explain your reasoning. (This problem extends the analysis begun in Solved Problem III on p. 201.)

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Genetics: From Genes to Genomes, 5th edition

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