A mutant form of polypeptide hormone angiotensin Il has the amino acid composition (Asp, Arg, Ile, Met, Phe, Pro, Tyr, Val) The following observations are made. • Trypsin yields a dipeptide containing Asp and Arg and a hexapeptide with all the rest. • Cyanogen bromide cleavage yields a dipeptide containing Phe and Pro and a hexapeptide containing all others. • Chymotrypsin cleaves the hormone into two tetrapeptides, of composition (Asp, Arg, Tyr, Val) and (Ile, Met, Phe, Pro) • The dipeptide of composition (Pro, Phe) cannot be cleaved by either chymotrypsin or carboxypeptidase What is the sequence of angiotensin II?

Biochemistry: Concepts and Connections

1st Edition

ISBN: 9780321839923

Author: Dean R. Appling, Spencer J. Anthony-Cahill, Christopher K. Mathews

Publisher: PEARSON

See similar textbooks

Concept explainers

Nucleotides

It is an organic molecule made up of three basic components- a nitrogenous base, phosphate,and pentose sugar. The nucleotides are important for metabolic reactions andthe formation of DNA (deoxyribonucleic acid) and RNA (ribonucleic acid).

Nucleic Acids

Nucleic acids are essential biomolecules present in prokaryotic and eukaryotic cells and viruses. They carry the genetic information for the synthesis of proteins and cellular replication. The nucleic acids are of two types: deoxyribonucleic acid (DNA) a…

Videos

Textbook Question

Chapter 5, Problem 9P

A mutant form of polypeptide hormone angiotensin Il has the amino acid composition (Asp, Arg, Ile, Met, Phe, Pro, Tyr, Val)
The following observations are made.
• Trypsin yields a dipeptide containing Asp and Arg and a hexapeptide with all the rest.
• Cyanogen bromide cleavage yields a dipeptide containing Phe and Pro and a hexapeptide containing all others.
• Chymotrypsin cleaves the hormone into two tetrapeptides, of composition (Asp, Arg, Tyr, Val) and (Ile, Met, Phe, Pro)
• The dipeptide of composition (Pro, Phe) cannot be cleaved by either chymotrypsin or carboxypeptidase

What is the sequence of angiotensin II?

Expert Solution & Answer

Want to see the full answer?

Check out a sample textbook solution

See solution

Chapter 5, Problem 8P

Chapter 5, Problem 10P

Students have asked these similar questions

Biochemistry What is the process of "transamination" in either the muscles or the liver, that involves keto acid or glutamic acid? Please explain how the steps work. Thank you!

Biochemistry Please help. Thank you What is the importance of glutamic acid in the metabolism of nitrogen from amino acids? (we know therole; it’s used to remove the nitrogen from amino acids so that the remaining carbon skeleton can bebroken down by the “usual” pathways, but what is the important, unique role that only glutamicacid/glutamate can do?)

Biochemistry Please help. Thank you When carbamyl phosphate is joined to L-ornathine, where does the energy for the reaction come from?

Knowledge Booster

Learn more about

Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biochemistry and related others by exploring similar questions and additional content below.

Concept explainers

Videos

Want to see the full answer?

Chapter 5 Solutions