Biochemistry: Concepts and Connections
1st Edition
ISBN: 9780321839923
Author: Dean R. Appling, Spencer J. Anthony-Cahill, Christopher K. Mathews
Publisher: PEARSON
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Textbook Question
Chapter 5, Problem 12P
a. Write a possible sequence for an mRNA segment coding for apamine.
b. Do you think apamine is synthesized in the form shown in Problem 11, or is it more likely a product of proteolytic cleavage of a larger peptide? Explain.
11. Apamine is a small protein toxin present in the venom of the honeybee. It has the sequence
CNCKAPETALCARRCQQH
a. If apamine does not react with iodoacetate (see Tools of Biochemistry 5B), then how many disulfide bonds are present?
b. If trypsin cleavage gave two peptides, then where is(are) the S-S bond(s)?
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12. When glutamic acid is heated to 180°C., it loses a molecule of water to form a
lactam. The bond that creates the lactam is an amide bond that forms between the
amino nitrogen and the carbon of the side chain -COOH group. What is the most
reasonable structure for this lactam? (NOTE: The structure of glutamic acid is shown
in Question 1.)
COOH
COOH
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C
D
COOH
B
COOH
E
COOH
10. Which one of the
following compounds is
the major organic product
of the series of reactions
shown here?
Ph
A
OH
Ph
B
CO₂Et
Br
-H
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CO₂Et
1. NaOEt
1. NaOH, H₂O
2. H3O+
2. PhCH2CH2Br
3. heat
NH2
Ph
OH
NH2
0
OH
Ph
OH
NH2
Ph
D
NH2
E
OH
1. What is the isoelectric point of glutamic acid?
(Glutamic acid has pKa1 2.10, pKa2 4.07, pKaз 9.47)
A) pH 2.1
D) pH 6.8
B) pH 3.1
C) pH 4.1
E) pH 9.5
HO
NH2
Glutamic acid
(shown without charges)
OH
Chapter 5 Solutions
Biochemistry: Concepts and Connections
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- Br Mg, ether 1. HCHO (formaldehyde) 2. H+, H₂O PCC 1. NH3, HCN ? (pyridinium chlorochromate) 2. H2O, HCI 11. Which one of the following compounds is the major organic product of the series of reactions shown above? Ph. Ph. OH NH2₂ A Ph. Ή NH2 B OH Ph Η Ph OH NH2 NH2₂ NH₂ C D Earrow_forwardB A 6. Which ONE of the labeled bonds in the tripeptide on the right is a peptide bond: H₂N N 'N' OH C H A, B, C, D or E? HN E OHarrow_forwardQuestions 8-9 are 0.4 points each. The next two questions relate to the peptide whose structure is shown here. To answer these questions, you should look at a table of H2N/.. amino acid structures. You don't have to memorize the structures of the amino acids. IZ 8. What is the N-terminal amino acid of this peptide? A) proline B) aspartic acid C) threonine 9. What is the C-terminal amino acid of this peptide? A) proline B) aspartic acid C) threonine N OH D) valine E) leucine D) valine E) leucine NH "OH OHarrow_forward
- 7. What is the correct name of the following tripeptide? A) Ile-Met-Ser B) Leu-Cys-Thr C) Val-Cys-Ser D) Ser-Cys-Leu E) Leu-Cys-Ser H₂N!!!!! N H ΖΙ .SH SF H IN OH OHarrow_forwardPlease draw out the following metabolic pathways: (Metabolic Map) Mitochondrion: TCA Cycle & GNG, Electron Transport, ATP Synthase, Lipolysis, Shuttle Systems Cytoplasm: Glycolysis & GNG, PPP (Pentose Phosphate Pathway), Glycogen, Lipogenesis, Transporters and Amino Acids Control: Cori/ Glc-Ala cycles, Insulin/Glucagon Reg, Local/Long Distance Regulation, Pools Used Correctlyarrow_forwardPlease help provide me an insight of what to draw for the following metabolic pathways: (Metabolic Map) Mitochondrion: TCA Cycle & GNG, Electron Transport, ATP Synthase, Lipolysis, Shuttle Systems Cytoplasm: Glycolysis & GNG, PPP (Pentose Phosphate Pathway), Glycogen, Lipogenesis, Transporters and Amino Acids Control: Cori/ Glc-Ala cycles, Insulin/Glucagon Reg, Local/Long Distance Regulation, Pools Used Correctlyarrow_forward
- f. The genetic code is given below, along with a short strand of template DNA. Write the protein segment that would form from this DNA. 5'-A-T-G-G-C-T-A-G-G-T-A-A-C-C-T-G-C-A-T-T-A-G-3' Table 4.5 The genetic code First Position Second Position (5' end) U C A G Third Position (3' end) Phe Ser Tyr Cys U Phe Ser Tyr Cys Leu Ser Stop Stop Leu Ser Stop Trp UCAG Leu Pro His Arg His Arg C Leu Pro Gln Arg Pro Leu Gin Arg Pro Leu Ser Asn Thr lle Ser Asn Thr lle Arg A Thr Lys UCAG UCAC G lle Arg Thr Lys Met Gly Asp Ala Val Gly Asp Ala Val Gly G Glu Ala UCAC Val Gly Glu Ala Val Note: This table identifies the amino acid encoded by each triplet. For example, the codon 5'-AUG-3' on mRNA specifies methionine, whereas CAU specifies histidine. UAA, UAG, and UGA are termination signals. AUG is part of the initiation signal, in addition to coding for internal methionine residues. Table 4.5 Biochemistry, Seventh Edition 2012 W. H. Freeman and Company B eviation: does it play abbreviation:arrow_forwardAnswer all of the questions please draw structures for major productarrow_forwardfor glycolysis and the citric acid cycle below, show where ATP, NADH and FADH are used or formed. Show on the diagram the points where at least three other metabolic pathways intersect with these two.arrow_forward
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