BIOLOGY
12th Edition
ISBN: 9781264839698
Author: Raven
Publisher: MCG CUSTOM
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Chapter 5, Problem 2IQ
Summary Introduction
To describe: The way in which one would recognize an integral membrane protein based only on the amino acid sequence.
Introduction: A cell membrane is also called a cytoplasmic membrane or plasma membrane. A transmembrane protein is a type of integral membrane protein. It spans the entirety of the cell membrane. The cell membranes consist of a variety of different transmembrane proteins.
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What sort of analysis is used to determine the properties of the amino acids in an integral membrane protein?
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Chapter 5 Solutions
BIOLOGY
Ch. 5.1 - Prob. 1LOCh. 5.1 - Explain the fluid mosaic model of membrane...Ch. 5.2 - List the different components of phospholipids.Ch. 5.2 - Prob. 2LOCh. 5.2 - Prob. 3LOCh. 5.3 - Illustrate the functions of membrane proteins.Ch. 5.3 - Prob. 2LOCh. 5.3 - Prob. 3LOCh. 5.4 - Compare simple diffusion and facilitated...Ch. 5.4 - Prob. 2LO
Ch. 5.4 - Prob. 3LOCh. 5.5 - Prob. 1LOCh. 5.5 - Prob. 2LOCh. 5.5 - Prob. 3LOCh. 5.6 - Distinguish between endocytosis and exocytosis.Ch. 5.6 - Illustrate how endocytosis can be specific.Ch. 5 - According to the fluid mosaic model, membranes are...Ch. 5 - Prob. 2IQCh. 5 - The fluid mosaic model of the membrane describes...Ch. 5 - What chemical property characterizes the interior...Ch. 5 - The transmembrane domain of an integral membrane...Ch. 5 - The specific function of a membrane within a cell...Ch. 5 - The movement of water across a membrane is...Ch. 5 - Prob. 6UCh. 5 - Which of the following is NOT a mechanism for...Ch. 5 - A bacterial cell that can alter the composition of...Ch. 5 - What variable(s) influence(s) whether a nonpolar...Ch. 5 - Which of the following does NOT contribute to the...Ch. 5 - How are active transport and coupled transport...Ch. 5 - A cell can use the process of facilitated...Ch. 5 - figure 5.5 describes a classic experiment...Ch. 5 - Each compartment of the endomembrane system of a...Ch. 5 - The distribution of lipids in the ER membrane is...
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- Part a) Would a single alpha helix be more stable in a aqueous solution or a membrane. Explain why. Part b) Why do transmembrane proteins always have secondary structures inside the membrane but aqueous proteins do not? Part c) If you had a single alpha helix, can it act as a pore for a membrane. Explain.arrow_forwardThe usual hydrophobic region of a membrane is around 30 Angstroms. Knowing this, about many amino acid residues would a transmembrane helix have?arrow_forwardB) We also know from studies of protein structure that one turn of an a-helix includes 3.6 amino acid residues and extends the long axis of the helix by - 0.56 nm. Approximately how many amino acids must a helical transmembrane segment of an integral membrane protein have if the segment is to span the lipid bilayer defined by two stearate molecules laid end to end, plus the polar head groups to which the stearate molecules are attached (assume a polar head group has a diameter of 0.5 nm)?arrow_forward
- What typical structure[s] is/are found in integral membrane proteins – how do they span themembrane?arrow_forwardConsider the amino acids on the image below. Which of the following amino acids would be most likely to be found in the part of an integral membrane protein that is located within the membrane? (Select all answers that apply.) Asparagine (Asn) Lysine (Lys) Phenylalanine (Phe) Valine (Val) Glutamic acid (Glu) Methionine (Met)arrow_forwardWhich amino acids would you expect to find buried in the interior of peripheral membrane protein ?arrow_forward
- At what level of protein structure (primary, secondary, tertiary, or quaternary) will protein structure be initially altered? A mutation in the genetic sequence, which ultimately causes an amino acid to change(e.g. Trp – Asn – His turns into Trp – Arg – His) Dissolving a protein in a non-polar solvent (like oil) instead of water.arrow_forwardChoose the statements that describe how the helix orients in the tertiary structure of an integral membrane protein. The threonine residues act as membrane interface anchors, interacting with the lipid bilayer and the aqueous environment. The amphipathic helix interacts with the lipid bilayer along its hydrophobic surface, exposing its hydrophilic surface to the aqueous environment. A group of helices cluster with their polar surfaces in contact with one another and their hydrophobic surfaces facing the lipid bilayer. The peptide entirely embeds in the lipid bilayer. Incorrectarrow_forwardGreen Fluorescent Protein has regions that are very hydrophobic. What is the meaning of “hydrophobic”? What causes a protein to be hydrophobic?arrow_forward
- Consider beta-sheet comprised of twelve amino acid residues (two strands of six residues each). How many hydrogen bonds should be formed between backbone atoms in this sheet?arrow_forwardWhy is having flexible and unstructured regions of a protein important for the function of the protein?arrow_forward1. Integral and peripheral membrane proteins employ multiple strategies to keep them associated to a biological membrane. View these three proteins below, and for each protein shown, answer the following questions: A) What type of membrane protein is this? Integral, peripheral, monotopic, polytopic? How do you know? Justify your label by features of the protein shown in the image. B) Describe the overall tertiary structure of each protein. Be certain to mention hydrophilicity/hydrophobicity of the surfaces of this protein. C) Provide a detailed description of how each protein is held associated to the biological membrane. Protein 2 Protein 3 Protein 1 "H,N. Exterior Cytosolarrow_forward
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The Cell Membrane; Author: The Organic Chemistry Tutor;https://www.youtube.com/watch?v=AsffT7XIXbA;License: Standard youtube license