Developmental Biology
11th Edition
ISBN: 9781605354705
Author: Scott F. Gilbert, Michael J. F. Barresi
Publisher: Sinauer Associates is an imprint of Oxford University Press
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Chapter 5, Problem 2DQ
Summary Introduction
To review:
The role of Notch/Delta and Hes gene oscillations during embryonic development in the adult neural stem cell niche. The oscillations result in the progression from stem cell to neuron.
Introduction:
Notch signaling plays important role in fate determination and the differentiation of neural stem cells in embryonic and adult brains. Notch signaling plays significant role in the maintenance of the pool of B type stem cells. Notch regulatory mechanism of neurogenesis lies in the downstream transcriptional targets named as Hairy and enhancer of split (Hes) related genes. These genes primarily function to repress proneural gene expression. Hes genes and specifically Hes1 are among the best-characterized Notch target genes.
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