FUND. OF ANATOMY & PHYSIOLOGY F16 PKG
10th Edition
ISBN: 9781323431122
Author: Martini
Publisher: PEARSON C
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Chapter 5, Problem 23CP
Summary Introduction
To determine:
Functions of sebaceous secretions
Concept introduction:
The sebaceous glands are exocrine glands present in the skin layer. They secrete sebum, which is composed of lipids like cholesterol and fatty acids. The secretory cells in the skin get ruptured to release the sebum. These secretions prevent the growth of the bacteria or other microorganisms. Sebaceous follicles are present in the skin, which secrete sebum into the epithelial cells.
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Digoxin: Intravenous Bolus - Two Compartment Model
Drug
Digoxin
Route:
IV Bolus
Dose:
0.750 mg
Plasma Concentration Time Profile
Beta
Alpha
Time (hrs)
Conc (ng/ml)
LN
(ng/ml)
LN
(ng/ml)
LN
0.00
#NUM!
#NUM!
#NUM!
0.10
12.290
2.509
#NUM!
#NUMI
0.60
6.975
1.942
#NUM!
#NUMI
1.00
4.649
1.537
#NUM!
#NUMI
2.00
2.201
0.789
#NUM!
#NUM!
3.00
1.536
0.429
#NUM!
#NUM!
4.00
1.342
0.294
#NUM!
#NUM!
5.00
1.273
0.241
#NUM!
#NUMI
6.00
1.238
0.213
#NUM!
#NUM!
7.00
1.212
0.192
#NUM!
#NUM!
8.00
1.188
0.172
#NUMI
#NUM!
9.00
1.165
0.153
#NUM!
#NUMI
10.00
1.143
0.134
#NUMI
#NUM!
11.00
1.122
0.115
#NUM!
12.00
1.101
0.096
#NUMI
13.00
1.080
0.077
#NUMI
16.00
1.020
0.020
#NUMI
24.00
0.876
-0.132
#NUMI
Pharmacokinetic Parameters
Parameter
Value
Alpha
B
Beta
Units
ng/ml
hr-1
ng/ml
hr-1
CO
ng/ml
H.C
AUC
ng x hr/ml
Vc
Vbeta
Vss
C
L/hr
TK (alpha)
hr
TX (beta)
days
5+
F3
F4
F5
0+
F6
F7
%
6
95
14
#3
29
&
t
F8
F9
FW
EW
Linuron, a derivative of urea, is used as an herbicide. Linuron serum levels were measured in 4Kg
rabbits following a bolus IV injection of 10mg/kg.
Time (minutes)
Serum Linuron Levels (ug/ml)
following IV dose
10
15.48
20
8.60
30
5.90
45
3.78
60
2.42
90
1.49
120
0.93
180
0.60
240
0.41
300
0.29
360
0.22
Analyze this data and perform the necessary calculations to determine the following pharmacokinetic
parameters from the IV data: (5 points per parameter, 24 parameters/variables ■ 120 points
possible). You do NOT need to submit graphs or data tables.
Give the terminal regression line equation and R or R² value:
Give the x axis (name and units, if any) of the terminal line:
Give the y axis (name and units, if any) of the terminal line:
Give the residual regression line equation and R or R² value:
Give the x axis (name and units, if any) of the residual line:
Give the y axis (name and units, if any) of the residual line:
Chapter 5 Solutions
FUND. OF ANATOMY & PHYSIOLOGY F16 PKG
Ch. 5 - Identity the layers of the epidermis.Ch. 5 - Dandruff is caused by excessive shedding of cells...Ch. 5 - A splinter that penetrates to the third layer of...Ch. 5 - Why does taking a bath cause wrinkly fingertips...Ch. 5 - Some criminals sand the Lips of their fingers so...Ch. 5 - Prob. 11CPCh. 5 - Prob. 13CPCh. 5 - Prob. 14CPCh. 5 - Prob. 15CPCh. 5 - Prob. 16CP
Ch. 5 - Prob. 12CPCh. 5 - Prob. 18CPCh. 5 - Prob. 17CPCh. 5 - Name the two major pigments in the epidermis.Ch. 5 - Why does exposure to sunlight darken skin?Ch. 5 - Prob. 8CPCh. 5 - Prob. 9CPCh. 5 - Prob. 10CPCh. 5 - Describe a typical strand of hair.Ch. 5 - What happens when the arrector pili muscle...Ch. 5 - Once a burn on the forearm that destroys the...Ch. 5 - Prob. 22CPCh. 5 - Prob. 23CPCh. 5 - Prob. 24CPCh. 5 - Which type of skin gland is most affected by the...Ch. 5 - Prob. 26CPCh. 5 - Prob. 27CPCh. 5 - Prob. 28CPCh. 5 - Prob. 29CPCh. 5 - Why can skin regenerate effectively even after...Ch. 5 - Prob. 31CPCh. 5 - Why does hair turn while or gray with age?Ch. 5 - Prob. 1RQCh. 5 - The two major components of the integumentary...Ch. 5 - Prob. 3RQCh. 5 - Prob. 4RQCh. 5 - Prob. 5RQCh. 5 - Prob. 6RQCh. 5 - Prob. 7RQCh. 5 - The accessory structures of the integument include...Ch. 5 - Prob. 9RQCh. 5 - Prob. 10RQCh. 5 - Prob. 11RQCh. 5 - The primary function of sensible perspiration is...Ch. 5 - Prob. 13RQCh. 5 - Prob. 14RQCh. 5 - Prob. 15RQCh. 5 - Prob. 16RQCh. 5 - Prob. 17RQCh. 5 - What two major layers constitute the dermis, and...Ch. 5 - List the four phases in the regeneration of the...Ch. 5 - Contrast insensible perspiration and sensible...Ch. 5 - Prob. 21RQCh. 5 - Prob. 22RQCh. 5 - Prob. 23RQCh. 5 - Prob. 24RQCh. 5 - Prob. 25RQCh. 5 - Prob. 26RQCh. 5 - Prob. 27RQCh. 5 - Prob. 28RQCh. 5 - Prob. 29RQCh. 5 - One of the factors to which lie detectors respond...Ch. 5 - Prob. 31RQCh. 5 - Prob. 1CCCh. 5 - Prob. 2CC
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