Genetics: Analysis and Principles
6th Edition
ISBN: 9781259616020
Author: Robert J. Brooker Professor Dr.
Publisher: McGraw-Hill Education
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Chapter 5, Problem 23CONQ
Genes that cause Prader-Willi syndrome and Angelman syndrome are closely linked along chromosome 15. Although people with these syndromes do not usually reproduce, let’s suppose that a couple produces two children with Angelman syndrome. The oldest child (named Pat) grows up and has two children with Prader-Willi syndrome. The second child (named Robin) grows up and has one child with Angelman syndrome.
A. Are Pat and Robin’s parents both
B. What are the sexes of Pat and Robin? Explain.
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Below is a pedigree from one family (two parents and eight children). Four of the children (indicated by shaded shapes) are affected with a serious disease with an unknown genetic cause.
a) For the disease, what pattern of inheritance (autosomal/sex-linked, recessive/dominant) is exhibited by this pedigree?
b) Linkage analysis of the disease to a series of VNTR polymorphisms on human chromosome 5 is shown above. Is there evidence for linkage between the disorder and the VNTR? Briefly explain your answer.
In humans, chromosome 16 sometimes has a heavily stained area near the
centromere. This feature can be seen in a microscope, but otherwise has no
effect on the phenotype of the person carrying it. When such a “blob" exists on
a given copy of chromosome 16, it is a constant feature of that chromosome
and is inherited.
A couple conceived a child, but the fetus had multiple abnormalities and was
miscarried. e.g., The fetus had three copies of chromosome 16, where 2 of the
3 copies of chromosome 16 had large blobs. Both of the mother's copies of
chromosome 16 lacked blobs, but the father was heterozygous for blobs. The
fetus was formed from a fertilization event that included a gamete produced
by the
in which nondisjunction occurred during the
meiotic
division.
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mother; first.
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father; second.
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Insufficient information is provided…
In humans, chromosome 16 sometimes has a heavily stained area in the long arm near the centromere. This feature can be seen through the microscope but has no effect on the phenotype of the person carrying it. When such a “blob” exists on a particular copy of chromosome 16, it is a constant feature of that chromosome and is inherited.
A couple conceived a child, but the fetus had multiple abnormalities and was miscarried. When the chromosomes of the fetus were studied, it was discovered that it had three copies of chromosome 16 (it was trisomic for chromosome 16), and that two of the three chromosome 16s had large blobs. Both chromosome 16 homologs in the mother lacked blobs, but the father was heterozygous for blobs.
Which parent experienced nondisjunction, and in which meiotic division did it occur?
Chapter 5 Solutions
Genetics: Analysis and Principles
Ch. 5.1 - A female snail that coils to the left has...Ch. 5.1 - 2. What is the molecular explanation for maternal...Ch. 5.2 - 1. In fruit flies, dosage compensation is achieved...Ch. 5.2 - 2. According to the Lyon hypothesis,
a. one of...Ch. 5.2 - Prob. 3COMQCh. 5.3 - 1. In mice, the copy of the Igf2 gene that is...Ch. 5.3 - 2. A female mouse that is is crossed to a male...Ch. 5.3 - Prob. 3COMQCh. 5.3 - Prob. 4COMQCh. 5.4 - 1. Extranuclear inheritance occurs due to
a....
Ch. 5.4 - 2. A cross is made between a green four-o’clock...Ch. 5.4 - 3. Some human diseases are caused by mutations in...Ch. 5.4 - 4. Chloroplasts and mitochondria evolved from an...Ch. 5 - Define the term epigenetic inheritance, and...Ch. 5 - 2. Describe the inheritance pattern of maternal...Ch. 5 - A maternal effect gene exists in a dominant N...Ch. 5 - 4. A Drosophila embryo dies during early...Ch. 5 - 5. For Mendelian inheritance, the nuclear genotype...Ch. 5 - Suppose a maternal effect gene exists as a...Ch. 5 - Suppose that a gene affects the anterior...Ch. 5 - Explain why maternal effect genes exert their...Ch. 5 - As described in Chapter 22, researchers have been...Ch. 5 - 10. With regard to the numbers of sex chromosomes,...Ch. 5 - 11. What is a Barr body? How is its structure...Ch. 5 - Among different species, describe three distinct...Ch. 5 - 13. Describe when X-chromosome inactivation occurs...Ch. 5 - 14. Describe the molecular process of X-chromosome...Ch. 5 - Prob. 15CONQCh. 5 - 16. How many Barr bodies would you expect to find...Ch. 5 - 17. Certain forms of human color blindness are...Ch. 5 - A black female cat (XBXB) and an orange male cat...Ch. 5 - Prob. 19CONQCh. 5 - When does the erasure and reestablishment phase of...Ch. 5 - In what types of cells would you expect de novo...Ch. 5 - 22. On rare occasions, people are born with a...Ch. 5 - Genes that cause Prader-Willi syndrome and...Ch. 5 - Prob. 24CONQCh. 5 - What is extranuclear inheritance? Describe three...Ch. 5 - Prob. 26CONQCh. 5 - Among different species, does extranuclear...Ch. 5 - Extranuclear inheritance often correlates with...Ch. 5 - Prob. 29CONQCh. 5 - Prob. 30CONQCh. 5 - Which of the following traits or diseases is (are)...Ch. 5 - Prob. 32CONQCh. 5 - 33. Describe how a biparental pattern of...Ch. 5 - Figure 5.1 describes an example of a maternal...Ch. 5 - 2. Discuss the types of experimental observations...Ch. 5 - Prob. 3EQCh. 5 - As a hypothetical example, a trait in mice results...Ch. 5 - You have a female snail that coils to the right,...Ch. 5 - Prob. 6EQCh. 5 - 7. Figure 5.6 describes the results of...Ch. 5 - Prob. 8EQCh. 5 - In the experiment of Figure 5.6, why does a clone...Ch. 5 - Prob. 10EQCh. 5 - 11. A variegated trait in plants is analyzed using...Ch. 5 - 1. Recessive maternal effect genes are identified...Ch. 5 - Prob. 2QSDC
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Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- Consider two hypothetical recessive autosomal genes a and b, where a heterozygote is testcrossed to a double- homozygous mutant. Predict the phenotypic ratios under the following conditions: (a) a and b are located on separate autosomes. (b) a and b are linked on the same autosome but are so far apart that a crossover always occurs between them. (c) a and b are linked on the same autosome but are so close together that a crossover almost never occurs.arrow_forward1. Duchenne’s muscular dystrophy (DMD) is a devastating X-linked recessive disease that causes muscle wasting and is eventually fatal. Meredith’s brother Craig has DMD but Meredith is healthy. You may find it beneficial to draw the family pedigree. a) What is the simple probability (as a percentage) that Meredith is a carrier of a mutation causing DMD? b) Meredith herself has two healthy children, a boy and a girl. Is this anterior (ancestral) or posterior (modifying) information? c) If Meredith IS a carrier for DMD (i.e. scenario A is correct), what is the probability (as a percentage) of her having these two healthy children?arrow_forwardTwo phenotypically normal parents produce a phenotypically abnormal child in which chromosome 5 is missing part of its long arm but has a piece of chromosome 7 attached to it. The child also has one normal copy of chromosome 5 and two normal copies of chromosome 7. With regard to chromosomes 5 and 7, what do you think are the chromosomal compositions of the parents? Would it most likely be reciprocal translocation? It wouldn't be simple translocation because then the child would have the entirety of one chromosome and only some of the other, but in this case, there is only partial chromosome 5 and chromosome 7?arrow_forward
- The following image shows a Robertsonian translocation between chromosomes 13 and 21. This has the potential to cause Down Syndrome in offspring. The couple had 6 pregnancies. What is the probable cause for the two miscarriages you see in the pedigree? See the legend for more information. Briefly explain your answer. male female miscarriage chromosome 13 chromosome 21 Robertsonian translocation Carrier Normal der(13;21)(q10;q10) Down syndrome Carrier Down syndrome Normal O DOarrow_forwardIn a sample of 1000 patients with Down syndrome, a geneticist discovers that 95% of them are trisomic, while 5% have diploid number of chromosomes. Explain this discrepancy.arrow_forwardA tomato geneticist attempts to assign five recessivemutations to specific chromosomes by using trisomics.She crosses each homozygous mutant (2n) with each ofthree trisomics, in which chromosomes 1, 7, and 10 takepart. From these crosses, the geneticist selects trisomicprogeny (which are less vigorous) and backcrosses themto the appropriate homozygous recessive. The diploidprogeny from these crosses are examined. Her results, inwhich the ratios are wild type:mutant, are as follows:Which of the mutations can the geneticist assign towhich chromosomes? (Explain your answer fully.)arrow_forward
- The mutant genes for vestigial wings and singed bristles are approximately 30 map units apart on chromosome II in Drosophila. Assume that a vestigial-winged female was mated to a singed-bristle male, and that the resulting F1 phenotypically wild type females were mated to vestigial singed males. Of 1000 offspring, which phenotype class would represent the product of crossing over between the genes, and how many would you expect? a) vestigial, 300 flies b) vestigial, 150 flies wild type, 300 flies d) singed, 150 flies e) vestigial, singed double mutants, 150 fliesarrow_forwardThe Klinefelter syndrome (disomy of the X chromosome in males) is a genetic disease caused by aneuploidy of the sex chromosomes in humans. Patients with the 47,XXY karyotype are male. Describe two genetic scenarios leading to patients with the Klinefelter syndrome.arrow_forwardTwo phenotypically unaffected parents produce two children with familial Down syndrome. Regarding chromosome 14 and 21, what are the chromosomal composition of the parents?arrow_forward
- Susan’s grandfather was deaf, and passed down a hereditary form of deafness within Susan’s family as shown in Figure Q19–12.A. Is this mutation most likely to be dominant or recessive?B. Is it carried on an autosome or a sex chromosome? Why?C. A complete SNP analysis has been done for all of the 11 grandchildren (4 affected, and 7 unaffected). In comparing these 11 SNP results, how long a haplotype block would you expect to find around the critical gene? How might you detect it?arrow_forward5) Cystic fibrosis is caused by a gene on chromosome 7 and results in the build-up of mucus in the lungs. Two parents who do not have cystic fibrosis have three children with the disease. What is the probability that their fourth child will also have cystic fibrosis? Explain.arrow_forwardTwo phenotypically unaffected parents produce two children withfamilial Down syndrome. With regard to chromosomes 14 and 21,what are the chromosomal compositions of the parents?arrow_forward
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