Chapter 4.8, Problem 1CR

Summary Introduction

The transfer RNA (tRNA) is one of the important components in translation. Prokaryotes contain nearly 60 different tRNAs and humans have 100-110 tRNAs. The tRNA is composed of 73 to 93 nucleotides, a short single-stranded molecule. The tRNA structure contains acceptor stem, D loop, anticodon loop, TᴪC loop, and variable loop. The acceptor stem is composed of seven base pairs and four single-stranded nucleotides. The acceptor stem provides a site for the attachment of amino acids to tRNA. It plays a crucial role in recognition of the specific tRNA by its unique aminoacyl-tRNA synthetase. This enzyme contributes the binding of the cognate or correct amino acid to the tRNA based on the corresponding anticodon.