Campbell Biology, Books a la Carte Plus Mastering Biology with eText -- Access Card Package (10th Edition)
10th Edition
ISBN: 9780133922851
Author: Jane B. Reece, Lisa A. Urry, Michael L. Cain, Steven A. Wasserman, Peter V. Minorsky, Robert B. Jackson
Publisher: PEARSON
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Textbook Question
Chapter 43.2, Problem 3CC
WHAT IF? Ø If both copies of a light-chain gene and a heavy-chain gene recombined in each (diploid) B cell, how would this affect B cell development and function?
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Match the following terms of B-cell development with the best definition.
Surrogate light chain
Allelic exclusion
Checkpoint 2
Checkpoint 1
Receptor editing
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expression of only one heavy chain allele and one light chain allele
Presence of completed BCR with mu heavy chain and kappa or lambda light chain
Presence of mu heavy chain and presence of pre-B-cell receptor
VpreB and lambda5 which combine with the heavy chain to form pre-B-cell receptor
Successive rearrangement of light chain genes after negative selection
What are two types of long-lived cells derived from the B cell lineage? Where are these cells located + what is their function?
Briefly, what are the 2 ‘checkpoints’ in development for the B cell? When do the B cells pause to proliferate and why is this step is important? Explain receptor editing.
Chapter 43 Solutions
Campbell Biology, Books a la Carte Plus Mastering Biology with eText -- Access Card Package (10th Edition)
Ch. 43.1 - Pus is both a sign of infection and an indicator...Ch. 43.1 - MAKE CONNECTIONS How do the molecules that...Ch. 43.1 - Prob. 3CCCh. 43.2 - Prob. 1CCCh. 43.2 - Prob. 2CCCh. 43.2 - WHAT IF? If both copies of a light-chain gene and...Ch. 43.3 - Prob. 1CCCh. 43.3 - Treatment of antibodies with a particular protease...Ch. 43.3 - Prob. 3CCCh. 43.4 - Prob. 1CC
Ch. 43.4 - Prob. 2CCCh. 43.4 - WHAT IF? How would a macrophage deficiency likely...Ch. 43 - In what ways does innate immunity protect the...Ch. 43 - Why is the adaptive immune response to an initial...Ch. 43 - Is immunological memory after a natural infection...Ch. 43 - Prob. 43.4CRCh. 43 - Prob. 1TYUCh. 43 - An epitope associates with which part of an...Ch. 43 - Prob. 3TYUCh. 43 - Level 2: Application/Analysis 4. Which of the...Ch. 43 - Prob. 5TYUCh. 43 - Prob. 6TYUCh. 43 - Prob. 7TYUCh. 43 - Prob. 8TYUCh. 43 - MAKE CONNECTIONS Contrast clonal selection with...Ch. 43 - EVOLUTION CONNECTION Describe one invertebrate...Ch. 43 - Prob. 11TYUCh. 43 - Prob. 12TYUCh. 43 - SYNTHESIZE YOUR KNOWLEDGE This photo shows a child...
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- Match the stage of B cell development with the rearrangement or expression of immunoglobulin genes. Stem cell Early pro-B cell Late pro-B cell Large pre-B cell Small pre-B cell Immature B cell ✓Choose... V-DJ rearranging germline configuration for both light and heavy chain genes D-J rearranging V-J rearranging u heavy chain plus lambda or kappa light chains on cell surface μ heavy chain made but light-chain genes in germline configuration Choose... Choose... ➡ →arrow_forwardDescribe VDJ recombination in the development of B cell. Include in your description the roles of RSS, RAG-1 and RAG-2 and other essential enzymes.arrow_forward1- B cell clones undergo somatic hypermutation in which structure? Group of answer choices A) Thymic cortex B) Bone marrow C) Primary focus D) Germinal center dark zone 2- During T cell development, the surrogate alpha chain (pTalpha) is considered analogous to the surrogate light chains (lambda5 and VpreB) expressed during B cell development. Which complexes do these surrogate protein chains help form in T cell and B cells, respectively? Group of answer choices A) Mature TCR and transitional B cell BCR B) Double positive thymocyte CD4/CD8 complex and mature naive B cell IgD/IgM complex C) preTCR and preBCR D) Thymic progenitor Notch receptor and early pro-B cell IL-7 receptorarrow_forward
- 1 It was stated that the Rh antigens are so sparsely scattered on the red cell surface that IgG molecules bound to the Rh antigens are too far apart to fix C1q. Therefore, complement-mediated hemolysis cannot be invoked to explain hemolytic disease of the newborn. By what mechanism are the red cells destroyed?arrow_forwardPls helparrow_forwardIn B cells, what mechanism ensures that only rearranged V genes are transcribed?arrow_forward
- (a) Identify both the cellular component and the location of the component that is responsible for producing the luciferase protein from mRNAs transcribed in the plasmid-containing T lymphocytes. Explain what dictates to the lymphocytes the correct order in which amino acids should be linked to form the luciferase protein.arrow_forwardB-cell development in the bone marrow is an inherently wasteful process. Nearly half of the pro-B cells produced will die without progressing to the next stage of development. This massive loss of pro-B cells is due to detrimental DJH rearrangements on both alleles of the immunoglobulin heavy-chain locus. the failure of the pro-B cell to make a complete immunoglobulin heavy-chain protein. the inability of many pro-B cells to proceed with rearranging a V₁ to their rearranged DJH sequence. the failure of many pro-B cells to up-regulate Pax5 and become committed to the B-cell lineage.arrow_forwardPlease answer fast How do autoimmune diseases like rheumatoid arthritis, Type I diabetes and Multiple Sclerosis develop? a. There is an error during clonal expansion that generates an over-abundance of non-specific lymphocytes.b. During clonal deletion, the TREG cells that suppress the development of autoimmune diseases are accidentally eliminated. c. During maturation, negative selection fails to eliminate Class II MCH phagocytes with autoreactive receptors at checkpoint 1. d. During maturation, negative selection fails to eliminate lymphocytes with autoreactive receptors at checkpoint 2.arrow_forward
- B cell engulfs pathogen antigen phagocyte engulfs pathogen B cell becomes activates B cell activates T cell antigen-presenting cell antigen- presenting B cell T cell activated T cell gives rise to gives rise to activated memory activated memory T cell T cell B cell B cell diagram 1 diagram 2arrow_forwardIs it possible for a B cell heavy chain to have non-templated nucleotides (N) but no p nucleotides (P)?arrow_forwardCompare and contrast the first and second checkpoint in B cell development (Include terms: Heavy & light chain, surrogate light chain, cell signaling, apoptosis).arrow_forward
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