Biology
4th Edition
ISBN: 9781259188121
Author: Peter Stiling, Robert Brooker, Linda Graham, Eric Widmaier
Publisher: McGraw-Hill Education
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Textbook Question
Chapter 42.3, Problem 1EQ
What was the hypothesis proposed by Gaser and Schlaug? How did Gaser and Schlaug test this hypothesis? What were the results of their experiment?
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Digoxin: Intravenous Bolus - Two Compartment Model
Drug
Digoxin
Route:
IV Bolus
Dose:
0.750 mg
Plasma Concentration Time Profile
Beta
Alpha
Time (hrs)
Conc (ng/ml)
LN
(ng/ml)
LN
(ng/ml)
LN
0.00
#NUM!
#NUM!
#NUM!
0.10
12.290
2.509
#NUM!
#NUMI
0.60
6.975
1.942
#NUM!
#NUMI
1.00
4.649
1.537
#NUM!
#NUMI
2.00
2.201
0.789
#NUM!
#NUM!
3.00
1.536
0.429
#NUM!
#NUM!
4.00
1.342
0.294
#NUM!
#NUM!
5.00
1.273
0.241
#NUM!
#NUMI
6.00
1.238
0.213
#NUM!
#NUM!
7.00
1.212
0.192
#NUM!
#NUM!
8.00
1.188
0.172
#NUMI
#NUM!
9.00
1.165
0.153
#NUM!
#NUMI
10.00
1.143
0.134
#NUMI
#NUM!
11.00
1.122
0.115
#NUM!
12.00
1.101
0.096
#NUMI
13.00
1.080
0.077
#NUMI
16.00
1.020
0.020
#NUMI
24.00
0.876
-0.132
#NUMI
Pharmacokinetic Parameters
Parameter
Value
Alpha
B
Beta
Units
ng/ml
hr-1
ng/ml
hr-1
CO
ng/ml
H.C
AUC
ng x hr/ml
Vc
Vbeta
Vss
C
L/hr
TK (alpha)
hr
TX (beta)
days
5+
F3
F4
F5
0+
F6
F7
%
6
95
14
#3
29
&
t
F8
F9
FW
EW
Linuron, a derivative of urea, is used as an herbicide. Linuron serum levels were measured in 4Kg
rabbits following a bolus IV injection of 10mg/kg.
Time (minutes)
Serum Linuron Levels (ug/ml)
following IV dose
10
15.48
20
8.60
30
5.90
45
3.78
60
2.42
90
1.49
120
0.93
180
0.60
240
0.41
300
0.29
360
0.22
Analyze this data and perform the necessary calculations to determine the following pharmacokinetic
parameters from the IV data: (5 points per parameter, 24 parameters/variables ■ 120 points
possible). You do NOT need to submit graphs or data tables.
Give the terminal regression line equation and R or R² value:
Give the x axis (name and units, if any) of the terminal line:
Give the y axis (name and units, if any) of the terminal line:
Give the residual regression line equation and R or R² value:
Give the x axis (name and units, if any) of the residual line:
Give the y axis (name and units, if any) of the residual line:
Chapter 42 Solutions
Biology
Ch. 42.1 - Core Skill: Connections Nervous systems are one of...Ch. 42.1 - Scientists have determined that the brain mass of...Ch. 42.2 - Prob. 1CCCh. 42.2 - Prob. 2CCCh. 42.2 - Prob. 3CCCh. 42.2 - Prob. 4CCCh. 42.3 - Prob. 1CCCh. 42.3 - What was the hypothesis proposed by Gaser and...Ch. 42.3 - Prob. 2EQCh. 42.3 - CoreSKILL Based on the results described here and...
Ch. 42 - A nerve net consists of a. bilateral neurons that...Ch. 42 - Prob. 2TYCh. 42 - Prob. 3TYCh. 42 - The white matter of the CNS is composed of a....Ch. 42 - Prob. 5TYCh. 42 - Prob. 6TYCh. 42 - Prob. 7TYCh. 42 - Prob. 8TYCh. 42 - In humans, the ______ blank hemisphere of the...Ch. 42 - ______ blank is a progressive disease that causes...Ch. 42 - Prob. 1CQCh. 42 - Prob. 2CQCh. 42 - Core Concept: Systems New properties of life...Ch. 42 - Discuss how the two parts of the nervous system of...Ch. 42 - List the three major divisions of the brain of...
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