Concept explainers
To discuss:
How alternative splicing partially explains the diversity of human protein that exceeds the number of human genes.
Introduction:
DNA is a genetic material consisting of a long stretch of
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- a) What role do transcription factors play in transcription? b) Describe mRNA splicing.arrow_forwarda) What are two differences between DNA and RNA? b) Does RNA have polarity? c) Describe how tRNA is charged with an amino acid. d) What is an anticodon and where is it located on the tRNA structure?arrow_forwardRenota, a 51-year-old Slavic woman, lived in Romania with her family on a pig farm. She routinely slaughtered pigs and cooked pork for family meals. She had a wide variety of recipes that called for pork. A few days after preparing one of her famous pork dishes, Renota experi- enced diarrhea, abdominal pain, and chronic indigestion. She went to her family physician and explained her symp- toms to him. The physician, who knew the family well and was familiar with the family business, immediately sus- pected a bacterial or parasitic infection. A stool sample for routine bacterial culture and 0&P study was collected from Renota and submitted to the local diagnostic laboratory. Routine processing procedures were conducted on the stool sample. Gross examination of the stool revealed a portion of the infecting worm (Fig. A). An egg, measuring 36 by 25 um (Fig. B), was seen on the permanent 0&P slide. No intestinal bacterial pathogens were isolated. Questions and Issues for…arrow_forward
- What thoughts after reading this: "The cases of Henrietta Lacks and the Tuskegee Syphilis Experiment call attention to ethical violations in medical research, particularly involving underrepresented groups. Both instances raise important issues around informed consent, exploitation, and the responsibility of researchers. Biomedical ethics is grounded in principles like autonomy, beneficence, and justice. In both the Lacks case and the Tuskegee study, these principles were ignored. Henrietta Lacks’ cells were taken without her consent, and the men in the Tuskegee study were denied treatment without their knowledge. These failures in ethical oversight have caused lasting harm to the trust marginalized communities have in the medical system. Institutional Review Boards (IRBs) are designed to ensure ethical standards in research by requiring informed consent and protecting participants from harm. However, in Lacks’ case and the Tuskegee study, no such protections were in place. These…arrow_forwardWhat are your thoughts on this subject: "The story of Henrietta Lacks highlights critical issues in biomedical ethics, researcher responsibility, and the exploitation of marginalized communities. Henrietta, an African American woman, had her cells taken without consent in 1951 during her treatment for cervical cancer at Johns Hopkins Hospital. These cells, known as HeLa cells, became pivotal in medical research, contributing to the development of vaccines and cancer treatments. However, Henrietta and her family were never informed or compensated for the use of her cells. This violation of informed consent, a core principle of biomedical ethics, mirrors broader patterns of exploitation seen in historical medical studies, such as the Tuskegee Syphilis Study, where African American men were used in experiments without their consent or proper treatment. These unethical practices were often justified by racist and paternalistic attitudes, perpetuating a deep mistrust in medical…arrow_forwardHenrietta Lacks's cells have easily been the most important human cell line used in research in the last 70 years. HeLa cells have been sold by pharmaceutical and laboratory technology companies, creating millions or billions of dollars of revenue and have contributed to a huge host of medical advances including several vaccines. Their use has changed the course of medicine for the good. However, there was no informed consent from Henrietta or her family at the time the cells were taken. In fact, Dr. Gey, who took the original cell sample from Henrietta even initially lied and said they came from a woman named "Helen Lane." So clearly he knew that there was something unethical about his actions. Henrietta Lacks died from the aggressive cervical cancer that the cells were harvested from. She never knew how important her cells would become. Shockingly, her family was never informed about her contributions to science and medicine until the 1973, more than 20 years after the sample was…arrow_forward
- Not use ai pleasearrow_forwardDraw a cell with 2n=4 chromosomes in anaphase II of meiosis. How is this different than anaphase of mitosis?arrow_forwardIn chickens comb shape is controlled by a pair of interacting unlinked gene loci each with two alleles, R,r and P,p. These genes interact in such a way to give four possible phenotypes, as follows: Walnut - requires one each of the dominant genes. Rose - requires a R and homozygous recessive for the p gene. Pea - requires a P and homozygous recessive for the r gene. Single - requires fully homozygous recessive. If two walnut comb chickens are mated and produce 1,000 offspring, and some of these 1,000 offspring are of the single combed variety. Please answer the following questions: a.___ How many of rose comb phenotype would you expect in the 1,000 offspring? A. 563, B. 438, C. 360, D. 188, E. 63 b.___ The evidence provided would result in the conclusion that the inheritance of comb form in chickens is a good example of a polygenic mode of inheritance. True OR False c.___ What would be the best way to describe the cross involved? 1. A true dihybrid cross…arrow_forward
- Match the following: A. Intron B. Enhancer sequence C. TATA box D. 5’ cap E. Exon F.Operator G. Poly-A tail sequence H. 3’UTR 1.___ part of mature mRNA that is instrumental in binding to the ribosome 2.___ part of the coding strand promoter region where the transcription initiation complex will form 3.___Sequence found in the upstream section of eukaryotic DNA, sometimes at very great distances that can result in the increase of the initiation and therefore transcription of genes.arrow_forwardMatch the following 1) ____Point mutation, 2)____Nonsense mutation, and 3) ____Silent mutation A. Mutations that result in an inappropriate stop codon and a polypeptide of improper length. B. These mutations alter the DNA sequence of nucleotides but does not result in any alteration to the polypeptide produced. C. This type of alteration of nucleic acid structure could be the result of an error in the proofreading performed by DNA polymerase. D. This type of polypeptide mutation results in one amino acid being altered but the length of the chain being the same.arrow_forwardMatch these: A.) Chargaff B.) Mendel C.) Griffith D.) Beadle E.) T.H. Morgan F.) Meselsen G.) Watson H) Crick I) Franklin 1.___Key 1950's investigations into the three-dimensional structure of the DNA molecule utilizing X-ray crystallography 2.___While investigating the organic molecules responsible for heredity this researcher used bacteria infecting viruses that had been manipulated to possess proteins and DNA with different radioactive labels. 3.___ While carrying out research with Drosophila melanogaster and the sex-linked characteristic of White eyes he and his coworkers were able to demonstrate the chromosomal theory of inheritance. 4.___While working with other researchers, using both Drosophila melanogaster and Neurospora crassa, was able to develop information supporting the one gene/one enzyme (protein) hypothesis 5.___While working in concert with a co-worker, utilizing cesium gradient centrifugationarrow_forward
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