EBK LIFE: THE SCIENCE OF BIOLOGY
11th Edition
ISBN: 8220103935432
Author: Sadava
Publisher: MAC HIGHER
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Chapter 41.1, Problem 2R
Summary Introduction
To review:
The
Introduction:
TLRs are a class of receptors involved in providing innate immunity. TLRs recognize a specific molecule or pattern called pathogen-associated molecular pattern (PAMP), which is present in many pathogens.
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Glu-His-Trp-Ser-Gly-Leu-Arg-Pro-Gly
The pKa values for the peptide's side chains, terminal amino groups, and carboxyl groups are provided in the table.
Amino acid Amino pKa Carboxyl pKa Side-chain pKa
glutamate
9.60
2.34
histidine
9.17
1.82
4.25
6.00
tryptophan
9.39
2.38
serine
9.15
2.21
glycine
9.60
2.34
leucine
9.60
2.36
arginine
9.04
2.17
12.48
proline
10.96
1.99
Calculate the net charge of the molecule at pH 3.
net charge at pH 3:
Calculate the net charge of the molecule at pH 8.
net charge at pH 8:
Calculate the net charge of the molecule at pH 11.
net charge at pH 11:
Estimate the isoelectric point (pl) for this peptide.
pl:
Chapter 41 Solutions
EBK LIFE: THE SCIENCE OF BIOLOGY
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