EBK GENERAL, ORGANIC, AND BIOLOGICAL CH
7th Edition
ISBN: 8220100853180
Author: STOKER
Publisher: CENGAGE L
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Textbook Question
Chapter 4.10, Problem 3QQ
The nitrate, sulfate, and phosphate ions have, respectively, the chemical formulas
- a. NO4−, SO42−, and PO43−
- b. NO3−, SO32−, and PO33−
- c. NO3−, SO42−, and PO43−
- d. no correct response
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 4 Solutions
EBK GENERAL, ORGANIC, AND BIOLOGICAL CH
Ch. 4.1 - Prob. 1QQCh. 4.1 - Prob. 2QQCh. 4.1 - Prob. 3QQCh. 4.2 - How many valence electrons are present in an atom...Ch. 4.2 - Prob. 2QQCh. 4.2 - Prob. 3QQCh. 4.2 - Prob. 4QQCh. 4.2 - Which of the following elements would have the...Ch. 4.3 - Prob. 1QQCh. 4.3 - Prob. 2QQ
Ch. 4.3 - Prob. 3QQCh. 4.4 - In terms of subatomic particles, a Ca2+ ion...Ch. 4.4 - Prob. 2QQCh. 4.4 - Prob. 3QQCh. 4.4 - Prob. 4QQCh. 4.5 - An atom with a 1s22s22p4 electron configuration...Ch. 4.5 - Prob. 2QQCh. 4.5 - Prob. 3QQCh. 4.5 - Prob. 4QQCh. 4.5 - Prob. 5QQCh. 4.6 - Prob. 1QQCh. 4.6 - Prob. 2QQCh. 4.6 - Prob. 3QQCh. 4.7 - What is the chemical formula of the ionic compound...Ch. 4.7 - What is the chemical formula of the ionic compound...Ch. 4.7 - Given that Z2 ions are present in the ionic...Ch. 4.7 - Prob. 4QQCh. 4.8 - Prob. 1QQCh. 4.8 - Which of the following is a correct description of...Ch. 4.9 - Prob. 1QQCh. 4.9 - Prob. 2QQCh. 4.9 - Prob. 3QQCh. 4.9 - Prob. 4QQCh. 4.9 - Prob. 5QQCh. 4.9 - Prob. 6QQCh. 4.9 - The correct name for the binary ionic compound...Ch. 4.9 - Prob. 8QQCh. 4.10 - Prob. 1QQCh. 4.10 - Which of the following statements about polyatomic...Ch. 4.10 - The nitrate, sulfate, and phosphate ions have,...Ch. 4.10 - Prob. 4QQCh. 4.11 - Prob. 1QQCh. 4.11 - Prob. 2QQCh. 4.11 - Prob. 3QQCh. 4.11 - Prob. 4QQCh. 4.11 - Prob. 5QQCh. 4.11 - What is the chemical formula for the compound...Ch. 4 - Contrast the two general types of chemical bonds...Ch. 4 - Contrast the two general types of chemical...Ch. 4 - How many valence electrons do atoms with the...Ch. 4 - How many valence electrons do atoms with the...Ch. 4 - Prob. 4.5EPCh. 4 - Prob. 4.6EPCh. 4 - Write the complete electron configuration for each...Ch. 4 - Write the complete electron configuration for each...Ch. 4 - Prob. 4.9EPCh. 4 - For each of the following pairs of representative...Ch. 4 - How many of the highlighted elements in the...Ch. 4 - How many of the highlighted elements in the...Ch. 4 - Draw Lewis symbols for atoms of each of the...Ch. 4 - Draw Lewis symbols for atoms of each of the...Ch. 4 - Each of the following Lewis symbols represents a...Ch. 4 - Each of the following Lewis symbols represents a...Ch. 4 - Prob. 4.17EPCh. 4 - Prob. 4.18EPCh. 4 - What is the chemical property of the noble gases...Ch. 4 - Prob. 4.20EPCh. 4 - Prob. 4.21EPCh. 4 - Prob. 4.22EPCh. 4 - Give the chemical symbol for each of the following...Ch. 4 - Give the chemical symbol for each of the following...Ch. 4 - What would be the chemical symbol for an ion with...Ch. 4 - What would be the chemical symbol for an ion with...Ch. 4 - Fill in the blanks in each line in the following...Ch. 4 - Fill in the blanks in each line in the following...Ch. 4 - Fill in the blanks in each line of the following...Ch. 4 - Fill in the blanks in each line of the following...Ch. 4 - Identify element X by giving its chemical symbol,...Ch. 4 - Prob. 4.32EPCh. 4 - Prob. 4.33EPCh. 4 - Prob. 4.34EPCh. 4 - Prob. 4.35EPCh. 4 - Draw Lewis symbols for the following ions. a. O2...Ch. 4 - What is the charge on the monatomic ion formed by...Ch. 4 - What is the charge on the monatomic ion formed by...Ch. 4 - Indicate the number of electrons lost or gained...Ch. 4 - Indicate the number of electrons lost or gained...Ch. 4 - Which noble gas has an electron configuration...Ch. 4 - Prob. 4.42EPCh. 4 - Which noble gas is isoelectronic with each of the...Ch. 4 - Which noble gas is isoelectronic with each of the...Ch. 4 - Prob. 4.45EPCh. 4 - Indicate whether or not each of the following...Ch. 4 - Prob. 4.47EPCh. 4 - Prob. 4.48EPCh. 4 - Prob. 4.49EPCh. 4 - Write the electron configuration of the following....Ch. 4 - How many valence electrons are present in each of...Ch. 4 - Prob. 4.52EPCh. 4 - Using Lewis structures, show how ionic compounds...Ch. 4 - Using Lewis structures, show how ionic compounds...Ch. 4 - The following Lewis symbols for ions have the...Ch. 4 - Prob. 4.56EPCh. 4 - Prob. 4.57EPCh. 4 - Prob. 4.58EPCh. 4 - Prob. 4.59EPCh. 4 - Prob. 4.60EPCh. 4 - The component elements for four binary ionic...Ch. 4 - Prob. 4.62EPCh. 4 - Write the complete chemical formula (symbol and...Ch. 4 - Write the complete chemical formula (symbol and...Ch. 4 - Write the chemical formula for the ionic compound...Ch. 4 - Prob. 4.66EPCh. 4 - Prob. 4.67EPCh. 4 - What is the chemical formula of the ionic compound...Ch. 4 - A representative element (X) forms an ion with a 2...Ch. 4 - A representative element (Z) forms an ion with a...Ch. 4 - Prob. 4.71EPCh. 4 - The following questions pertain to the ionic...Ch. 4 - Prob. 4.73EPCh. 4 - Prob. 4.74EPCh. 4 - Prob. 4.75EPCh. 4 - Prob. 4.76EPCh. 4 - Prob. 4.77EPCh. 4 - Prob. 4.78EPCh. 4 - Prob. 4.79EPCh. 4 - Which of the following binary compounds would be...Ch. 4 - Name the following binary ionic compounds, each of...Ch. 4 - Name the following binary ionic compounds, each of...Ch. 4 - Calculate the charge on the metal ion in the...Ch. 4 - Calculate the charge on the metal ion in the...Ch. 4 - Prob. 4.85EPCh. 4 - Prob. 4.86EPCh. 4 - Prob. 4.87EPCh. 4 - Prob. 4.88EPCh. 4 - Name each of the following binary ionic compounds....Ch. 4 - Name each of the following binary ionic compounds....Ch. 4 - Prob. 4.91EPCh. 4 - Name each compound in the following pairs of...Ch. 4 - Prob. 4.93EPCh. 4 - Write chemical formulas for the following binary...Ch. 4 - Prob. 4.95EPCh. 4 - Write chemical formulas for the following binary...Ch. 4 - Prob. 4.97EPCh. 4 - Prob. 4.98EPCh. 4 - Fill in the blanks in each line of the following...Ch. 4 - Prob. 4.100EPCh. 4 - Prob. 4.101EPCh. 4 - Prob. 4.102EPCh. 4 - Prob. 4.103EPCh. 4 - How many oxygen atoms are present in each of the...Ch. 4 - Prob. 4.105EPCh. 4 - Prob. 4.106EPCh. 4 - Prob. 4.107EPCh. 4 - Prob. 4.108EPCh. 4 - Prob. 4.109EPCh. 4 - Prob. 4.110EPCh. 4 - How many ions are present per formula unit in each...Ch. 4 - Prob. 4.112EPCh. 4 - Name the following compounds, all of which contain...Ch. 4 - Prob. 4.114EPCh. 4 - Prob. 4.115EPCh. 4 - Prob. 4.116EPCh. 4 - Prob. 4.117EPCh. 4 - Write formulas for the following compounds, all of...Ch. 4 - Write chemical formulas for the following...Ch. 4 - Write chemical formulas for the following...Ch. 4 - Prob. 4.121EPCh. 4 - Prob. 4.122EPCh. 4 - Prob. 4.123EPCh. 4 - Prob. 4.124EP
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