FOUND.IN MICROBIOLOGY-ACCESS >CUSTOM<
10th Edition
ISBN: 9781266032264
Author: TALARO
Publisher: MCG CUSTOM
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Textbook Question
Chapter 4.1, Problem 2ELO
Identify the primary properties that define life and living things.
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Digoxin: Intravenous Bolus - Two Compartment Model
Drug
Digoxin
Route:
IV Bolus
Dose:
0.750 mg
Plasma Concentration Time Profile
Beta
Alpha
Time (hrs)
Conc (ng/ml)
LN
(ng/ml)
LN
(ng/ml)
LN
0.00
#NUM!
#NUM!
#NUM!
0.10
12.290
2.509
#NUM!
#NUMI
0.60
6.975
1.942
#NUM!
#NUMI
1.00
4.649
1.537
#NUM!
#NUMI
2.00
2.201
0.789
#NUM!
#NUM!
3.00
1.536
0.429
#NUM!
#NUM!
4.00
1.342
0.294
#NUM!
#NUM!
5.00
1.273
0.241
#NUM!
#NUMI
6.00
1.238
0.213
#NUM!
#NUM!
7.00
1.212
0.192
#NUM!
#NUM!
8.00
1.188
0.172
#NUMI
#NUM!
9.00
1.165
0.153
#NUM!
#NUMI
10.00
1.143
0.134
#NUMI
#NUM!
11.00
1.122
0.115
#NUM!
12.00
1.101
0.096
#NUMI
13.00
1.080
0.077
#NUMI
16.00
1.020
0.020
#NUMI
24.00
0.876
-0.132
#NUMI
Pharmacokinetic Parameters
Parameter
Value
Alpha
B
Beta
Units
ng/ml
hr-1
ng/ml
hr-1
CO
ng/ml
H.C
AUC
ng x hr/ml
Vc
Vbeta
Vss
C
L/hr
TK (alpha)
hr
TX (beta)
days
5+
F3
F4
F5
0+
F6
F7
%
6
95
14
#3
29
&
t
F8
F9
FW
EW
Linuron, a derivative of urea, is used as an herbicide. Linuron serum levels were measured in 4Kg
rabbits following a bolus IV injection of 10mg/kg.
Time (minutes)
Serum Linuron Levels (ug/ml)
following IV dose
10
15.48
20
8.60
30
5.90
45
3.78
60
2.42
90
1.49
120
0.93
180
0.60
240
0.41
300
0.29
360
0.22
Analyze this data and perform the necessary calculations to determine the following pharmacokinetic
parameters from the IV data: (5 points per parameter, 24 parameters/variables ■ 120 points
possible). You do NOT need to submit graphs or data tables.
Give the terminal regression line equation and R or R² value:
Give the x axis (name and units, if any) of the terminal line:
Give the y axis (name and units, if any) of the terminal line:
Give the residual regression line equation and R or R² value:
Give the x axis (name and units, if any) of the residual line:
Give the y axis (name and units, if any) of the residual line:
3.
In the tomato, red fruit (O+) is dominant over orange fruit (0), and yellow flowers (W+) are dominant over white
flowers (w). A cross was made between true-breeding plants with red fruit and yellow flowers, and plants with
orange fruit and white flowers. The F₁ plants were then crossed to plants with orange fruit and white flowers, which
produced the following results:
a.
b.
333 red fruit, yellow flowers
64 red fruit, white flowers
58 orange fruit, yellow flowers
350 orange fruit, white flowers
Conduct a chi-square analysis to demonstrate that these two genes DO NOT assort independently. Make sure
to interpret the P value obtained from your chi-square test.
Calculate and provide the map distance (in map units) between the two genes.
Chapter 4 Solutions
FOUND.IN MICROBIOLOGY-ACCESS >CUSTOM<
Ch. 4.1 - Describe the fundamental characteristics of cells.Ch. 4.1 - Identify the primary properties that define life...Ch. 4.1 - Prob. 1CYPCh. 4.1 - Name several general characteristics that could be...Ch. 4.2 - Describe the generalized anatomy of bacterial...Ch. 4.2 - Prob. 4ELOCh. 4.2 - Describe the structure and position of bacterial...Ch. 4.2 - Explain how flagella influence motility and motile...Ch. 4.2 - Prob. 7ELOCh. 4.2 - Define glycocalyx, and describe its different...
Ch. 4.2 - What other microbial groups besides bacteria have...Ch. 4.2 - Prob. 4CYPCh. 4.2 - How does the flagellum dictate the behavior of a...Ch. 4.2 - Differentiate between the structure and functions...Ch. 4.2 - Prob. 7CYPCh. 4.2 - Prob. 8CYPCh. 4.2 - Prob. 9CYPCh. 4.2 - Explain how the bacterial glycocalyx and certain...Ch. 4.3 - Prob. 9ELOCh. 4.3 - Outline the structure and functions of cell walls,...Ch. 4.3 - Contrast the major structure of gram-positive and...Ch. 4.3 - Prob. 12ELOCh. 4.3 - Relate the characteristics of other types of cell...Ch. 4.3 - Prob. 14ELOCh. 4.3 - Prob. 11CYPCh. 4.3 - Prob. 12CYPCh. 4.3 - Prob. 13CYPCh. 4.3 - How does the precise structure of the cell walls...Ch. 4.3 - Prob. 15CYPCh. 4.3 - Prob. 16CYPCh. 4.3 - Describe the medical impact of the cell walls of...Ch. 4.3 - Prob. 18CYPCh. 4.3 - Prob. 19CYPCh. 4.4 - Prob. 15ELOCh. 4.4 - Prob. 16ELOCh. 4.4 - Characterize the bacterial ribosomes and...Ch. 4.4 - Prob. 18ELOCh. 4.4 - Prob. 19ELOCh. 4.4 - Discuss the resistance and significance of...Ch. 4.4 - Prob. 20CYPCh. 4.4 - What is unique about the structure of bacterial...Ch. 4.4 - Prob. 22CYPCh. 4.4 - Prob. 23CYPCh. 4.4 - Describe the way endospores are formed, their...Ch. 4.4 - Prob. 25CYPCh. 4.4 - Why are spores so difficult to destroy?Ch. 4.5 - Describe the shapes of bacteria and their possible...Ch. 4.5 - Prob. 22ELOCh. 4.5 - Outline the size ranges among bacteria and in...Ch. 4.5 - Prob. 27CYPCh. 4.5 - Prob. 28CYPCh. 4.5 - What are vibrios and coccobacilli?Ch. 4.5 - Prob. 30CYPCh. 4.5 - Prob. 31CYPCh. 4.5 - Prob. 32CYPCh. 4.6 - Prob. 24ELOCh. 4.6 - Prob. 25ELOCh. 4.6 - Outline a basic system of bacterial taxonomy.Ch. 4.6 - Explain the species and subspecies levels for...Ch. 4.6 - Prob. 33CYPCh. 4.6 - Prob. 34CYPCh. 4.6 - Prob. 35CYPCh. 4.7 - Differentiate various groups of photosynthetic...Ch. 4.7 - Characterize the types of obligate intracellular...Ch. 4.7 - Prob. 30ELOCh. 4.7 - Prob. 31ELOCh. 4.7 - Prob. 32ELOCh. 4.7 - Prob. 36CYPCh. 4.7 - Name two main groups of obligate intracellular...Ch. 4.7 - Explain the characteristics of archaea that...Ch. 4.7 - Prob. 39CYPCh. 4.7 - Describe the three major archaeal lifestyles and...Ch. 4.L1 - Prob. 1MCQCh. 4.L1 - Viruses are not considered living things because...Ch. 4.L1 - Prob. 3MCQCh. 4.L1 - Prob. 4MCQCh. 4.L1 - Pili are appendages in _________ bacteria that...Ch. 4.L1 - Prob. 6MCQCh. 4.L1 - Which of the following is a primary bacterial cell...Ch. 4.L1 - Which of the following is present in both...Ch. 4.L1 - Metachromatic granules are concentrated ________...Ch. 4.L1 - Prob. 10MCQCh. 4.L1 - Prob. 11MCQCh. 4.L1 - Prob. 12MCQCh. 4.L1 - Prob. 13MCQCh. 4.L1 - Prob. 14MCQCh. 4.L1 - Prob. 15MCQCh. 4.L1 - To which taxonomic group do cyanobacteria belong?...Ch. 4.L1 - Prob. 17MCQCh. 4.L1 - The first living cells on earth would most likely...Ch. 4.L1 - Prob. 1CSRCh. 4.L1 - Prob. 2CSRCh. 4.L1 - What is a biofilm, and how did it form on the...Ch. 4.L1 - Label the parts on the bacterial cell featured...Ch. 4.L1 - Discuss the collection of properties that are used...Ch. 4.L1 - Describe the basic process of biofilm formation.Ch. 4.L1 - Prob. 4WCCh. 4.L1 - Prob. 5WCCh. 4.L2 - Using clay, demonstrate how cocci can divide in...Ch. 4.L2 - Prob. 2CTCh. 4.L2 - Prob. 3CTCh. 4.L2 - Prob. 4CTCh. 4.L2 - a. Name a bacterial group that uses chlorophyll to...Ch. 4.L2 - Propose a hypothesis to explain how bacteria and...Ch. 4.L2 - Prob. 7CTCh. 4.L2 - Prob. 8CTCh. 4.L2 - Describe the shapes and arrangements of bacteria...Ch. 4.L2 - Prob. 1VCCh. 4.L2 - What kinds of cells are shown here? Explain what...
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