Chapter 4, Problem 2P

Summary Introduction

To examine:  Whether the statement “The four core histones are relatively small proteins with a very high proportion of positively charged amino acids; the positive charge helps the histones bind tightly to DNA, regardless of its nucleotide sequence” is true or false.

Concept introduction: Histones are proteins rich in basic amino acids which help to compact and package the DNA into smaller structural units called nucleosomes. Histones are of the following types in the eukaryotic organisms: H1, H2A, H2B, H3 and H4. The terminals of the histones undergo several modifications like acetylation, methylation.