Fundamentals of Anatomy & Physiology, Custom edition for Houston Community College Northwest, Volume 1, Includes student access code card
18th Edition
ISBN: 9781323627983
Author: Martini, Nath, Bartholomew
Publisher: PEARSON
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Chapter 4, Problem 15RQ
Summary Introduction
Introduction:
The axons are the long cylindrical structure found on the neurons that conducts the signal from one cell to other cells. The dendrites are the branched outgrowth that emerges from the cell body of the nucleus; the dendrites receive the information from other neuronal cells. The cell body is the largest part of the nucleus that comprises of nucleus and a prominent nucleolus.
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
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2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
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Chapter 4 Solutions
Fundamentals of Anatomy & Physiology, Custom edition for Houston Community College Northwest, Volume 1, Includes student access code card
Ch. 4 - Define histology.Ch. 4 - Identify the four major types of tissues in the...Ch. 4 - Identify four essential functions of epithelial...Ch. 4 - List five important characteristics of epithelial...Ch. 4 - Prob. 5CPCh. 4 - Identify the various type of epithelial cell...Ch. 4 - What is the functional significance of gap...Ch. 4 - Identify the three cell shapes characteristic of...Ch. 4 - When classifying epithelial tissue, one with a...Ch. 4 - Viewed with a light microscope, a tissue appears...
Ch. 4 - Why do the pharynx, esophagus, anus, and vagina...Ch. 4 - Prob. 12CPCh. 4 - The secretory cells of sebaceous glands fill with...Ch. 4 - Prob. 14CPCh. 4 - Prob. 15CPCh. 4 - List the three categories of connective tissues.Ch. 4 - Prob. 17CPCh. 4 - Prob. 18CPCh. 4 - Prob. 19CPCh. 4 - Prob. 20CPCh. 4 - Prob. 21CPCh. 4 - Which two types of connective tissue have a fluid...Ch. 4 - Describe the recirculation of fluid in the body.Ch. 4 - Identify the two types of supporting connective...Ch. 4 - Prob. 25CPCh. 4 - Prob. 26CPCh. 4 - Identify the four types of tissue membranes found...Ch. 4 - Prob. 28CPCh. 4 - Which type of tissue membrane typically lines body...Ch. 4 - Prob. 30CPCh. 4 - Prob. 31CPCh. 4 - If skeletal muscle cells in adults are incapable...Ch. 4 - A tissue contains irregularly shaped cells with...Ch. 4 - Identify the two phases in the response to tissue...Ch. 4 - Prob. 35CPCh. 4 - Identify some age-related factors that affect...Ch. 4 - What would account for the observed increase in...Ch. 4 - LEVEL 1 Reviewing Facts and Terms 1. Identify the...Ch. 4 - Prob. 2RQCh. 4 - Tissue that is specialized for contraction is (a)...Ch. 4 - Prob. 4RQCh. 4 - The most abundant connections between cells in the...Ch. 4 - Prob. 6RQCh. 4 - Prob. 7RQCh. 4 - Prob. 8RQCh. 4 - Which of the following epithelia most easily...Ch. 4 - Functions of connective tissue include (a)...Ch. 4 - Prob. 11RQCh. 4 - Prob. 12RQCh. 4 - Prob. 13RQCh. 4 - Prob. 14RQCh. 4 - Prob. 15RQCh. 4 - Prob. 16RQCh. 4 - Prob. 17RQCh. 4 - Prob. 18RQCh. 4 - Prob. 19RQCh. 4 - Prob. 20RQCh. 4 - Prob. 21RQCh. 4 - Prob. 22RQCh. 4 - What is the difference between an exocrine...Ch. 4 - A significant structural feature in the digestive...Ch. 4 - Prob. 25RQCh. 4 - Prob. 26RQCh. 4 - A layer of glycoproteins and a network of fine...Ch. 4 - Why does damaged cartilage heal slowly? (a)...Ch. 4 - List the similarities and differences among the...Ch. 4 - Assuming that you had the necessary materials to...Ch. 4 - Prob. 31RQCh. 4 - While in a chemistry lab, Jim accidentally spills...Ch. 4 - Connective tissues are made up of specialized...Ch. 4 - Do you think this genetic syndrome affects just...
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