Biology: The Unity and Diversity of Life (MindTap Course List)
15th Edition
ISBN: 9781337408332
Author: Cecie Starr, Ralph Taggart, Christine Evers, Lisa Starr
Publisher: Cengage Learning
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Chapter 39, Problem 5SQ
Summary Introduction
Introduction: The small intestine is the major organ in human body that is involved in the absorption of major nutrients, minerals, and water. The digested food from the stomach passes through the small intestine, and the cells present in the small intestinal wall absorb the nutrients and transport them to the blood vessels. The blood vessels carry them to the different parts of the body.
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 39 Solutions
Biology: The Unity and Diversity of Life (MindTap Course List)
Ch. 39 - Human Adaptation to a Starchy Diet The human AMY-1...Ch. 39 - Human Adaptation to a Starchy Diet The human AMY-1...Ch. 39 - Human Adaptation to a Starchy Diet The human AMY-1...Ch. 39 - Prob. 1SQCh. 39 - Prob. 2SQCh. 39 - Prob. 3SQCh. 39 - A bird's keratin-lined _______ helps it grind up...Ch. 39 - Prob. 5SQCh. 39 - Prob. 6SQCh. 39 - The low pH of the _______ aids in protein...
Ch. 39 - Prob. 8SQCh. 39 - Prob. 9SQCh. 39 - Eating a healthy diet entirely of plant foods...Ch. 39 - Prob. 11SQCh. 39 - Prob. 12SQCh. 39 - Prob. 13SQCh. 39 - Match each substance with its description. _____...Ch. 39 - Match each organ with its digestive function in...Ch. 39 - Some people who have gallstones experience pain...Ch. 39 - A python can survive by eating a large meal once...Ch. 39 - Although rabbits cannot break cellulose down into...Ch. 39 - Cholera is a disease caused by bacteria that make...
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