Biology 2e
2nd Edition
ISBN: 9781947172517
Author: Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher: OpenStax
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Chapter 36, Problem 27CTQ
What can be inferred about the relative sizes of the areas of cortex that process signals from skin not densely innervated with sensory receptors and skin that is densely innervated with sensory receptors?
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
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2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…
The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?
Chapter 36 Solutions
Biology 2e
Ch. 36 - Figure 36.5 Which of the following statements...Ch. 36 - Figure 36.14 Cochlear implants can restore hearing...Ch. 36 - Figure 36.18 Which of the following statements...Ch. 36 - Where does perception occur? spinal cord cerebral...Ch. 36 - If a person’s cold receptors no longer convert...Ch. 36 - After somatosensory transduction, the sensory...Ch. 36 - Many people experience motion sickness while...Ch. 36 - ________ are found only in skin, and detect skin...Ch. 36 - If you were to burn your epidermis, what receptor...Ch. 36 - Many diabetic patients are warned by their doctors...
Ch. 36 - Which of the following has the fewest taste...Ch. 36 - How many different taste molecules do taste cells...Ch. 36 - Salty foods activate the taste cells by. exciting...Ch. 36 - All sensory signals except_____travel to The...Ch. 36 - How is the ability to recognize the umami taste an...Ch. 36 - In sound, pitch is measured in____T and ____...Ch. 36 - Auditory hair cells are indirectly anchored to the...Ch. 36 - Which of the following are found both in the...Ch. 36 - Benign Paroxysmal Positional Vertigo is a disorder...Ch. 36 - Why do people over 55 often need reading glasses?...Ch. 36 - Why is it easier to see images at night using...Ch. 36 - A person catching a ball must coordinate her head...Ch. 36 - A satellite is launched into space, but explodes...Ch. 36 - If a person sustains damage to axons leading from...Ch. 36 - In what way does the overall magnitude of a...Ch. 36 - Describe the difference in the localization of the...Ch. 36 - What can be inferred about the relative sizes of...Ch. 36 - Many studies have demonstrated that women are able...Ch. 36 - From the perspective of the recipient of the...Ch. 36 - What might be the effect on an animal of not being...Ch. 36 - A few recent cancer detection studies have used...Ch. 36 - How would a rise in altitude likely affect the...Ch. 36 - How might being in a place with less gravity than...Ch. 36 - How does the structure of the ear allow a person...Ch. 36 - How could the pineal gland, the brain structure...Ch. 36 - How is the relationship between photoreceptors and...Ch. 36 - Cataracts, the medical condition where the lens of...
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