Biology 2e
2nd Edition
ISBN: 9781947172517
Author: Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher: OpenStax
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Textbook Question
Chapter 36, Problem 8RQ
________ are found only in skin, and detect skin deflection.
- Meissner’s corpuscles; hairy
- Merkel’s disks; glabrous
- hair receptors; hairy
- Krause end bulbs; hairy
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 36 Solutions
Biology 2e
Ch. 36 - Figure 36.5 Which of the following statements...Ch. 36 - Figure 36.14 Cochlear implants can restore hearing...Ch. 36 - Figure 36.18 Which of the following statements...Ch. 36 - Where does perception occur? spinal cord cerebral...Ch. 36 - If a person’s cold receptors no longer convert...Ch. 36 - After somatosensory transduction, the sensory...Ch. 36 - Many people experience motion sickness while...Ch. 36 - ________ are found only in skin, and detect skin...Ch. 36 - If you were to burn your epidermis, what receptor...Ch. 36 - Many diabetic patients are warned by their doctors...
Ch. 36 - Which of the following has the fewest taste...Ch. 36 - How many different taste molecules do taste cells...Ch. 36 - Salty foods activate the taste cells by. exciting...Ch. 36 - All sensory signals except_____travel to The...Ch. 36 - How is the ability to recognize the umami taste an...Ch. 36 - In sound, pitch is measured in____T and ____...Ch. 36 - Auditory hair cells are indirectly anchored to the...Ch. 36 - Which of the following are found both in the...Ch. 36 - Benign Paroxysmal Positional Vertigo is a disorder...Ch. 36 - Why do people over 55 often need reading glasses?...Ch. 36 - Why is it easier to see images at night using...Ch. 36 - A person catching a ball must coordinate her head...Ch. 36 - A satellite is launched into space, but explodes...Ch. 36 - If a person sustains damage to axons leading from...Ch. 36 - In what way does the overall magnitude of a...Ch. 36 - Describe the difference in the localization of the...Ch. 36 - What can be inferred about the relative sizes of...Ch. 36 - Many studies have demonstrated that women are able...Ch. 36 - From the perspective of the recipient of the...Ch. 36 - What might be the effect on an animal of not being...Ch. 36 - A few recent cancer detection studies have used...Ch. 36 - How would a rise in altitude likely affect the...Ch. 36 - How might being in a place with less gravity than...Ch. 36 - How does the structure of the ear allow a person...Ch. 36 - How could the pineal gland, the brain structure...Ch. 36 - How is the relationship between photoreceptors and...Ch. 36 - Cataracts, the medical condition where the lens of...
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