Biology: The Unity and Diversity of Life (MindTap Course List)
15th Edition
ISBN: 9781337408332
Author: Cecie Starr, Ralph Taggart, Christine Evers, Lisa Starr
Publisher: Cengage Learning
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Chapter 35, Problem 15SQ
Match the words with their defining feature.
| _____ | osteoblast | a. conveys excitatory signal |
| _____ | myofibril | b. in the hands |
| _____ | myoglobin | c. bone-forming cell |
| _____ | knee | d. main thin filament protein |
| _____ | actin | e. produces blood cells |
| _____ | red marrow | f. donates phosphate to ADP |
| _____ | metacarpal | g. binds and releases oxygen |
| _____ | T tubule | h. a synovial joint |
| _____ | creatine phosphate | i. composed of sarcomeres |
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 35 Solutions
Biology: The Unity and Diversity of Life (MindTap Course List)
Ch. 35 - Prob. 1DAACh. 35 - Prob. 2DAACh. 35 - Prob. 3DAACh. 35 - Prob. 4DAACh. 35 - An endoskeleton consists of _________. a. a fluid...Ch. 35 - Prob. 2SQCh. 35 - Prob. 3SQCh. 35 - A ligament connects ________. a. bones at a joint...Ch. 35 - Prob. 5SQCh. 35 - The ___ attaches to the pelvic girdle. a. radius...
Ch. 35 - The ________ is the basic unit of contraction. a....Ch. 35 - In sarcomeres, phosphate-group transfers from ATP...Ch. 35 - A sarcomere shortens when ________. a. thick...Ch. 35 - Prob. 10SQCh. 35 - Prob. 11SQCh. 35 - A motor unit is _________. a. a muscle and the...Ch. 35 - _______ from a motor neuron excites a muscle...Ch. 35 - The sarcoplasmic reticulum stores and releases...Ch. 35 - Match the words with their defining feature. _____...Ch. 35 - Continued strenuous activity can cause lactate to...Ch. 35 - After death, calcium pumps no longer function and...Ch. 35 - Bully whippets are homozygous for a deletion of...Ch. 35 - Athletes tend to have stronger bones than...
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